This submission responds to the RFA for an Exploratory NCMHD Center for Excellence (RFA-MD-08- 0049). We propose to examine the distributions of two biomarkers in a large, ongoing, well-characterized longitudinal study of African Americans, the Jackson Heart Study, and to characterize their association with a number of known risk factors for metabolic syndrome (MetS), type 2 diabetes mellitus (T2D) and cardiovascular disease (CVD), with a long-term aim of identifying more precisely the plasma levels that would alert a primary care provider to those who are most likely to benefit from treatment. We will assess the relevance of family history by estimating familial correlations and the heritability. In addition to examining plasma levels of ghrelin and PAI-1, we wish to examine them in the context of other risk factors, including obesity and genetic risk factors in GWAS analyses. Specifically, this study aims to describe the distribution of plasma levels of ghrelin and PAI-1 and their heritability in the Jackson Heart Study (JHS) cohort, examine environmental and genetic correlations between plasma ghrelin and PAI-1 levels and factors predictive of heart disease in the JHS cohort, and find polymorphisms and haplotypes associated with plasma ghrelin and PAI-1 levels in the JHS. Because ghrelin plays a significant role in energy homeostasis via the hypothalamus by controlling food intake, and is a powerful orexigenic and adipogenic agent in human physiology, it is important to study this biomarker in a cohort at the epicenter of the obesity epidemic. Ghrelin's effect on metabolism is thought to be the opposite of leptin's, and these two peptide hormones may act synergistically to increase insulin resistance and metabolic abnormalities Leptin was assayed in the JHS exam 1. We propose to assay both ghrelin and leptin in exam 3, and to assay ghrelin in exam 1. Analysis of exam 1 biomarker data in conjunction with measures of obesity in exam 3, such as BMI, waist circumference, hip to waist ratio, as well as imaging data providing measures of visceral and subcutaneous adiposity and their ratio, will allow us to determine if the biomarkers play a predictive role in the development of obesity.
| Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2018) Food Insecurity and Cardiovascular Disease Risk Factors among Mississippi Adults. Int J Environ Res Public Health 15: |
| Sims, Jennifer N; Yedjou, Clement G; Abugri, Daniel et al. (2018) Racial Disparities and Preventive Measures to Renal Cell Carcinoma. Int J Environ Res Public Health 15: |
| Horowitz, Carol R; Shameer, Khader; Gabrilove, Janice et al. (2017) Accelerators: Sparking Innovation and Transdisciplinary Team Science in Disparities Research. Int J Environ Res Public Health 14: |
| Mendy, Vincent L; Vargas, Rodolfo; Payton, Marinelle (2017) Trends in mortality rates by subtypes of heart disease in Mississippi, 1980-2013. BMC Cardiovasc Disord 17:158 |
| Dehghani Firouzabadi, Ali; McDonald, Tiffany C; Samms, Tametria R et al. (2017) Disparities in HIV Clinical Outcomes among a Cohort of HIV-Infected Persons Receiving Care-Mississippi. Int J Environ Res Public Health 14: |
| Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2017) Overweight, Obesity, and Extreme Obesity Among Mississippi Adults, 2001-2010 and 2011-2015. Prev Chronic Dis 14:E49 |
| Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2017) Electronic Cigarette Use among Mississippi Adults, 2015. J Addict 2017:5931736 |
| Balakrishnan, Revathi; Kaplan, Benjamin; Negron, Rennie et al. (2017) Life after Stroke in an Urban Minority Population: A Photovoice Project. Int J Environ Res Public Health 14: |
| Addison, Clifton; Jenkins, Brenda W Campbell; White, Monique et al. (2017) Perception of Policy and Environmental Action to Promote Healthy Behaviors in African American Communities. Int J Environ Res Public Health 14: |
| Divers, Jasmin; Palmer, Nicholette D; Langefeld, Carl D et al. (2017) Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes. BMC Genet 18:105 |
Showing the most recent 10 out of 197 publications
