Symptom management is an important component of nursing practice across care settings, client populations, and type of practice. Although the value of symptom management is widely recognized, the research base supporting practice is uneven with extensive research on pain and pain management and little research addressing symptoms like constipation, thirst, itching, hot flashes in men, and fatigue in chronic heart failure. Symptom management research is quite broad in scope. It includes identification of previously uncharacterized symptoms, examination of approaches to symptom reporting, describing symptom appraisals and symptom interpretation, documenting the pattern of a specific symptom or examining the patterns of relationships among a variety of symptoms, testing interventions designed to prevent or ameliorate a symptom or those aimed at modifying responses to symptoms, and the systematic evaluation of strategies for translating knowledge about symptom management into practice. The experience of life-threatening illness is especially relevant to the science of symptom management because symptoms are a key element of the illness experience.
The aims of the proposed exploratory center are to advance the state-of-the-art for knowledge development and utilization on symptom management in life-threatening illness (cancer, cardiac disease, and end-of-life care), establish a new methodologic standard for symptom management research, develop an infrastructure to symptom management research at the OHSU SON, and enhance the existing research environment. The Center will provide funding for three pilot/feasibility studies each year for three years and provide shared resources to support these pilot studies in the areas of Statistical Analysis, Methodologic Support, and Logistical Support. The Center is built on a strong research base that includes two NIH-funded R01's and additional NIH funded symptom management studies as well as foundation funded projects. The leadership team includes two senior level and one experienced mid-career scientist, all of whom address aspects of symptom management in their own programs of research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Exploratory Grants (P20)
Project #
5P20NR007807-03
Application #
6659864
Study Section
Special Emphasis Panel (ZNR1-REV-A (30))
Program Officer
Bakos, Alexis D
Project Start
2001-09-15
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2003
Total Cost
$239,501
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Nursing
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Elsea, Collin R; Roberts, Daniel A; Druker, Brian J et al. (2008) Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity. PLoS One 3:e2355
Winters-Stone, Kerri M; Bennett, Jill A; Nail, Lillian et al. (2008) Strength, physical activity, and age predict fatigue in older breast cancer survivors. Oncol Nurs Forum 35:815-21
Nail, Lillian M (2006) Cognitive changes in cancer survivors. Cancer and cancer treatment often cause cognitive deficits, but no guidelines exist for screening or treatment. Am J Nurs 106:48-54
Wood, Lisa J; Nail, Lillian M; Perrin, Nancy A et al. (2006) The cancer chemotherapy drug etoposide (VP-16) induces proinflammatory cytokine production and sickness behavior-like symptoms in a mouse model of cancer chemotherapy-related symptoms. Biol Res Nurs 8:157-69
Wood, Lisa J; Nail, Lillian M; Gilster, April et al. (2006) Cancer chemotherapy-related symptoms: evidence to suggest a role for proinflammatory cytokines. Oncol Nurs Forum 33:535-42
Nail, Lillian M (2006) Cognitive changes in cancer survivors. Cancer Nurs 29:48-54
Fromme, Erik K; Tilden, Virginia P; Drach, Linda L et al. (2004) Increased family reports of pain or distress in dying Oregonians: 1996 to 2002. J Palliat Med 7:431-42
Nail, Lillian M (2004) My get up and go got up and went: fatigue in people with cancer. J Natl Cancer Inst Monogr :72-5
Hickman, Susan E; Tilden, Virginia P; Tolle, Susan W (2004) Family perceptions of worry, symptoms, and suffering in the dying. J Palliat Care 20:20-7