Abstract

Meningiomas are amongst the most commonly encountered intracranial and spinal cord associated tumors. While the majority of these tumors are clinically benign, a proportion of them develop into highly aggressive malignant neoplasms. While active efforts are being directed towards the cloning and identification of the """"""""meningioma initiating locus"""""""" on chromosome 22, the molecular basis of the progression to malignancy of meningiomas is unknown and the histopathological grading of these tumors often controversial. The major objective of this study will be to use cytogenetics and highly polymorphic DNA markers to detect loss of heterozygosity in different grades of meningiomas, and thereby correlate tumor histopathology with specific molecular events in the DNA of these tumors. The identification f such chromosomal regions will set the stage for future studies in which the genes that are involved in tumor progression can be identified and cloned.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Exploratory Grants (P20)
Project #
5P20NS031145-02
Application #
3783285
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

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Li, B; Paradies, N E; Brackenbury, R W (1997) Isolation and characterization of the promoter region of the chicken N-cadherin gene. Gene 191:7-13
Shinoura, N; Chen, L; Wani, M A et al. (1996) Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy. J Neurosurg 84:839-45;discussion 846
Simon, M; Kokkino, A J; Warnick, R E et al. (1996) Role of genomic instability in meningioma progression. Genes Chromosomes Cancer 16:265-9
Ess, K; Chen, H; Kier, A et al. (1995) Suppression of tumorigenicity, but not invasion, in glioblastoma/HeLa cell hybrids. J Cell Physiol 162:341-7
Shinoura, N; Paradies, N E; Warnick, R E et al. (1995) Expression of N-cadherin and alpha-catenin in astrocytomas and glioblastomas. Br J Cancer 72:627-33
Simon, M; von Deimling, A; Larson, J J et al. (1995) Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression. Cancer Res 55:4696-701
Larson, J J; Tew Jr, J M; Simon, M et al. (1995) Evidence for clonal spread in the development of multiple meningiomas. J Neurosurg 83:705-9

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