This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to use two brain scanning techniques, magnetic resonance spectroscopy (MRS) and blood oxygenation-level dependent functional MRI (BOLD fMRI), to determine how aging changes the brain chemicals and function in patients infected with HIV. The study will include 150 HIV and HIV negative patients. We will enroll 75 HIV-seropositive patients and 75 HIV-seronegative control subjects. The majority of the subjects will be screened and enrolled at Leahi Hospital, University of Hawaii campuses, and other community centers. Once enrolled, the subjects will go to the Queen s Medical Center (QMC) for the subject visits and MR scans. Methods and techniques that will be used for the studies include the evaluation of HIV disease severity (in the HIV-seropositive subjects) bloodwork, history and physical, neuropsychological tests and spinal taps will be performed on all subjects consenting. In subjects that fulfill the study criteria, a set of MRI studies will be perform (which includes standard structural MRI, BOLD fMRI measurement of visual attention and working memory, and localized proton magnetic resonance spectroscopy to assess brain chemistry).
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