Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study investigates a condition known as Polycystic Ovary Syndrome (PCOS). This condition causes irregular periods, inability to get pregnant, and excessive facial and body hair. The United States Food and Drug Administration approve the drug used in this study, Metformin, for the treatment of Type II diabetes. However, it is commonly used for your condition (PCOS) because of your inability to properly process insulin, a hormone that controls blood sugar. This study is designed to examine the effects of the drug, metformin XR, which causes the body to be more sensitive to insulin, combined with exercise versus a placebo (pill with no medication) combined with exercise in females with Polycystic Ovary Syndrome on the frequency of egg release from the ovaries, hyperandrogenemia (increased levels of male hormones) and your sensitivity to insulin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR011792-09
Application #
7381059
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
9
Fiscal Year
2006
Total Cost
$96,920
Indirect Cost

  Institution

Name
Meharry Medical College
Department
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208

  Publications

Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-309
Wilkerson, Irene; Laban, Joshua; Mitchell, Johnathan M et al. (2015) Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. J Neuroinflammation 12:2
Marrs, Christy N; Knobel, Susan M; Zhu, Wen Qin et al. (2012) Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. Microbes Infect 14:500-8
Alcendor, Donald J; Charest, Ashley M; Zhu, Wen Qin et al. (2012) Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation 9:95
Miller, Stephania T; Marolen, Khensani (2012) Physical activity-related experiences, counseling expectations, personal responsibility, and altruism among urban African American women with type 2 diabetes. Diabetes Educ 38:229-35
Rice, Valerie Montgomery; Maimbolwa, Margaret C; Nkandu, Esther Munalula et al. (2012) Cultural differences in acceptability of a vaginal microbicide: a comparison between potential users from Nashville, Tennessee, USA, and Kafue and Mumbwa, Zambia. HIV AIDS (Auckl) 4:73-80
Sledzi?ska, A; Mielech, A; Krawczyk, B et al. (2011) Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping. BJOG 118:266-9
Sharan, Chakradhari; Halder, Sunil K; Thota, Chandrasekhar et al. (2011) Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril 95:247-53
Alcendor, Donald J; Knobel, Susan; Desai, Prashant et al. (2011) KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol 179:1443-54
Choudhury, Shahana A; Ladson, Gwinnett; Hills, Edward R et al. (2011) Waning immunity to varicella in infants of human immunodeficiency virus-seropositive and -seronegative mothers. Pediatr Infect Dis J 30:799-801

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