This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Multicenter double blind, Phase III, placebo controlled clinical trial. SELECT will include 32,400 healthy male participants. Participants will be randomized to receive either 200 ug of selenium, 400 mg of vitamin E, both or placebos for up to 12 years. Accrual is expected to take five years and seven years of follow-up is planned once accrual is completed. The purpose of this study is to compre the effects (good and bad) of the study supplements. The supplements are selenium (L-selenomethionine), vitamin E (alpha-tocopherol), selenium plus vitamin E, and placebo (a pill containing no active substances). We want to see whether the supplements, other than the placebo, can prevent or reduce the occurrence of prostate cancer. The primary objective of SELECT is to assess the effect of selenium and vitamin E on the incidence of prostate cancer diagnozed during routine clinical practice. Secondary objectives include assessing the impact of selenium and vitamin E on the incidence of lung and colon cancer and on cancer specific survival and overall survival. Quality of life, evaluation of molecular and genetic markers of cancer risk, other biomarkers, and measure of nutrient intake will also be assessed.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
3P20RR011792-10S2
Application #
7960735
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-08-01
Project End
2009-09-30
Budget Start
2007-08-01
Budget End
2009-09-30
Support Year
10
Fiscal Year
2009
Total Cost
$14,440
Indirect Cost
Name
Meharry Medical College
Department
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-309
Wilkerson, Irene; Laban, Joshua; Mitchell, Johnathan M et al. (2015) Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. J Neuroinflammation 12:2
Marrs, Christy N; Knobel, Susan M; Zhu, Wen Qin et al. (2012) Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. Microbes Infect 14:500-8
Alcendor, Donald J; Charest, Ashley M; Zhu, Wen Qin et al. (2012) Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus. J Neuroinflammation 9:95
Miller, Stephania T; Marolen, Khensani (2012) Physical activity-related experiences, counseling expectations, personal responsibility, and altruism among urban African American women with type 2 diabetes. Diabetes Educ 38:229-35
Rice, Valerie Montgomery; Maimbolwa, Margaret C; Nkandu, Esther Munalula et al. (2012) Cultural differences in acceptability of a vaginal microbicide: a comparison between potential users from Nashville, Tennessee, USA, and Kafue and Mumbwa, Zambia. HIV AIDS (Auckl) 4:73-80
Choudhury, Shahana A; Ladson, Gwinnett; Hills, Edward R et al. (2011) Waning immunity to varicella in infants of human immunodeficiency virus-seropositive and -seronegative mothers. Pediatr Infect Dis J 30:799-801
Sledzi?ska, A; Mielech, A; Krawczyk, B et al. (2011) Fatal sepsis in a pregnant woman with pyelonephritis caused by Escherichia coli bearing Dr and P adhesins: diagnosis based on postmortem strain genotyping. BJOG 118:266-9
Sharan, Chakradhari; Halder, Sunil K; Thota, Chandrasekhar et al. (2011) Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril 95:247-53
Alcendor, Donald J; Knobel, Susan; Desai, Prashant et al. (2011) KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. Am J Pathol 179:1443-54

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