This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this Core are to provide facilities and technical expertise in support of projects involving mouse models as a means of addressing important biological and biomedical questions. This Core was established in the previous funding period through a combination of Institutional and COBRE support. L. Liaw has managed all aspects of this Core and is fully responsible for its outstanding success. This Core has been heavily used by all basic science investigators for the generation of transgenic and gene-targeted strains of mice. Due to high demand for transgenic mouse services and the need to become self-sufficient when COBRE funds are no longer available to support this Core, a fee-for-service schedule has been implemented. In April 2005, our Magnetic Resonance Imaging (MRI) facility came on-line, let by Dr. Ilka Pinz, who was recruited in March 2005. At this time, operational protocols are: anatomical imaging, angiography in large vessels, proton spectroscopy, cardiac images and diastolic/systolic dimensions of the ventricle, in utero assessment of embryo development. We will be hiring a full time Research Assistant to staff the MRI facility March 2006.
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