This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.There is very strong evidence from epidemiological and basic science studies to suggest that obesity may increase the risk of asthma. This has very important implications for the health of the US population given the current parallel epidemics of obesity and asthma. Understanding the physiological and inflammatory changes induced by obesity would make an important contribution to our understanding of the relationship between obesity and asthma. It is also important to understand why some obese people develop asthma, but others do not. We hypothesize that obese people with asthma have altered adipose tissue related inflammation compared to obese people without asthma. We also hypothesize that weight loss will improve physiological and inflammatory measures of asthmaWe have assembled a multi-disciplinary team, including surgeons, endocrinologists and pulmonologists to study patients undergoing gastric bypass surgery for extreme obesity. We are studying obese patients with asthma before surgery and in the 12 months after surgery: we are studying (i) their lung function with sophisticated physiological techniques before and after surgery (ii) adipose-related inflammation by in vitro studies on visceral and subcutaneous fat collected at the time of surgery (iii) circulating pro-inflammatory factors produced by adipose tissue and (iv) inflammation in the lung by bronchoscopy with isolation of cells by bronchoalveolar lavage for in vitro studies. As a comparison group we are also studying obese patients without asthma to determine if there are differences in adipose tissue-related factors that could explain why they do not have asthma.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015557-08
Application #
7609702
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
8
Fiscal Year
2007
Total Cost
$297,039
Indirect Cost
Name
University of Vermont & St Agric College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Szalayova, Gabriela; Ogrodnik, Aleksandra; Spencer, Brianna et al. (2016) Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent cancer cell proliferation. Breast Cancer Res Treat 157:461-74
Cruz, Fernanda F; Borg, Zachary D; Goodwin, Meagan et al. (2016) CD11b+ and Sca-1+ Cells Exert the Main Beneficial Effects of Systemically Administered Bone Marrow-Derived Mononuclear Cells in a Murine Model of Mixed Th2/Th17 Allergic Airway Inflammation. Stem Cells Transl Med 5:488-99
Ather, Jennifer L; Burgess, Edward J; Hoyt, Laura R et al. (2016) Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. J Immunol 197:1720-32
Menon, Prema R; Stapleton, Renee D; McVeigh, Ursula et al. (2015) Telemedicine as a tool to provide family conferences and palliative care consultations in critically ill patients at rural health care institutions: a pilot study. Am J Hosp Palliat Care 32:448-53
Kasahara, David I; Ninin, Fernanda M C; Wurmbrand, Alison P et al. (2015) Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency. Clin Exp Allergy 45:457-70
Lathrop, M J; Sage, E K; Macura, S L et al. (2015) Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesothelioma. Cancer Gene Ther 22:44-54
Dixon, Anne E; Gerald, Lynn B (2015) Promoting weight loss in asthma. Respirology 20:179-80
Cruz, Fernanda F; Borg, Zachary D; Goodwin, Meagan et al. (2015) Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice. Stem Cells Transl Med 4:615-24
Cruz, Fernanda F; Borg, Zachary D; Goodwin, Meagan et al. (2015) Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice. Stem Cells Transl Med 4:1302-16
Lathrop, Melissa J; Brooks, Elice M; Bonenfant, Nick R et al. (2014) Mesenchymal stromal cells mediate Aspergillus hyphal extract-induced allergic airway inflammation by inhibition of the Th17 signaling pathway. Stem Cells Transl Med 3:194-205

Showing the most recent 10 out of 158 publications