This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The significance of our current findings is that they demonstrate that the fluorescent viruses are infectious and thus will be excellent platforms for carrying out the fitness evaluations proposed. Moreover the finding that in our pulse chase analyses that there are significant alterations in processing and in gp120shedding is almost certain to have impact on the outcome of other phenotypic evaluations such as incorporation and fusion. These parameters, in turn will impact fitness. Therefore it seems likely that the system will detect fitness differences and those differences will be attributable to amino acid polymorphismsbetween different C2-V4 regions.
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