This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pharmacological stimulation of parasympathetic nervous system cholinergic action provides protective effects against cardiac remodeling and dysfunction. In contrast, lack of cholinergic muscarinic type 2 receptors, the major receptors that mediate control of the heart, results in cardiac dysfunction. A long-term goal of my research is to investigate PSNS cardio protective effects and the underlying mechanisms.
The specific aim of this pilot study is to test a hypothesis that chronic left vagus nerve stimulation provides a protection against cardiac remodeling and dysfunction via enhancing PSNS cholinergic action.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015567-10
Application #
7959618
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
10
Fiscal Year
2009
Total Cost
$12,392
Indirect Cost
Name
University of South Dakota
Department
Neurosciences
Type
Schools of Medicine
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069
Burrell, Brian D (2017) Comparative biology of pain: What invertebrates can tell us about how nociception works. J Neurophysiol 117:1461-1473
Robertson, James M; Achua, Justin K; Smith, Justin P et al. (2017) Anxious behavior induces elevated hippocampal Cb2 receptor gene expression. Neuroscience 352:273-284
Novick, Andrew M; Mears, Mackenzie; Forster, Gina L et al. (2016) Adolescent social defeat alters N-methyl-D-aspartic acid receptor expression and impairs fear learning in adulthood. Behav Brain Res 304:51-9
Smith, Justin P; Prince, Melissa A; Achua, Justin K et al. (2016) Intensity of anxiety is modified via complex integrative stress circuitries. Psychoneuroendocrinology 63:351-61
Ranek, Mark J; Zheng, Hanqiao; Huang, Wei et al. (2015) Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload. J Mol Cell Cardiol 85:273-81
Hahn, Elizabeth; Burrell, Brian (2015) Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech. Invert Neurosci 15:177
Novick, Andrew M; Forster, Gina L; Hassell, James E et al. (2015) Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stress. Neuropharmacology 97:194-200
Robertson, James M; Prince, Melissa A; Achua, Justin K et al. (2015) Nuance and behavioral cogency: How the Visible Burrow System inspired the Stress-Alternatives Model and conceptualization of the continuum of anxiety. Physiol Behav 146:86-97
Ranek, Mark J; Kost Jr, Curtis K; Hu, Chengjun et al. (2014) Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner. J Mol Cell Cardiol 69:43-51
Watt, Michael J; Roberts, Christina L; Scholl, Jamie L et al. (2014) Decreased prefrontal cortex dopamine activity following adolescent social defeat in male rats: role of dopamine D2 receptors. Psychopharmacology (Berl) 231:1627-36

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