Abstract

We will recruit a new investigator with expertise in apoptosis/cell death, inflammation, and/or neuroimmunology. The rationale for expanding in this area is that inflammation and immune-mediated events initiated after CNS trauma contribute significantly to tissue loss and subsequently decreased function. In addition, these processes are also initiated after restorative therapies such as cell transplantation and blocking that will lead to enhanced graft survival. Expertise in these areas will contribute significantly to all of the Projects in this COBRE and Projects 1-4 will provide alternative systems in which to test hypothesis generated in Project 5. Thus, there will be significant collaboration of Project 5 with the other Projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015576-03
Application #
6630071
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Louisville
Department
Type
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Kuypers, Nicholas J; Bankston, Andrew N; Howard, Russell M et al. (2016) Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation. J Neurosci 36:1698-710
Myers, Scott A; Bankston, Andrew N; Burke, Darlene A et al. (2016) Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials? Exp Neurol 283:560-72
Ward, P J; Herrity, A N; Harkema, S J et al. (2016) Training-Induced Functional Gains following SCI. Neural Plast 2016:4307694
May, Zacnicte; Fouad, Karim; Shum-Siu, Alice et al. (2015) Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion. Behav Brain Res 291:26-35
Ward, Patricia J; Herrity, April N; Smith, Rebecca R et al. (2014) Novel multi-system functional gains via task specific training in spinal cord injured male rats. J Neurotrauma 31:819-33
Jagadapillai, Rekha; Mellen, Nicholas M; Sachleben Jr, Leroy R et al. (2014) Ceftriaxone preserves glutamate transporters and prevents intermittent hypoxia-induced vulnerability to brain excitotoxic injury. PLoS One 9:e100230
Nielson, Jessica L; Guandique, Cristian F; Liu, Aiwen W et al. (2014) Development of a database for translational spinal cord injury research. J Neurotrauma 31:1789-99
Kuypers, Nicholas J; James, Kurtis T; Enzmann, Gaby U et al. (2013) Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord. Exp Neurol 247:615-22
Schultz, R L; Kullman, E L; Waters, R P et al. (2013) Metabolic adaptations of skeletal muscle to voluntary wheel running exercise in hypertensive heart failure rats. Physiol Res 62:361-9
Burke, Darlene A; Whittemore, Scott R; Magnuson, David S K (2013) Consequences of common data analysis inaccuracies in CNS trauma injury basic research. J Neurotrauma 30:797-805

Showing the most recent 10 out of 150 publications