Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
Our specific aims have changed based on new data that we obtained. After consulting with the Program Director, we will test the hypothesis that intrinsic mechanisms for axon growth is programmed in the developmental stage and turned off after CNS maturation. We are attempting to rejuvenate this mechanism by modulation of Id2 and SnoN transcription factors that may promote axonal regeneration after SCI. As a result of the data outlined below, this work has been submitted to the NIH as an R01 Feb 08.
Aim 1 : Determine the role of Id2 in neurite sprouting from DRG neurons, as well as axon regeneration in the dorsal columns following a T8 dorsal hemisection.
Aim 2 : Determine the role of SnoN in neurite sprouting, and axon regeneration following T8 dorsal hemisection.
Aim 3 : Explore combinatorial strategies using CSPG digestion and MPI blocking to maximize axon regeneration and functional recovery following SCI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015576-09
Application #
7720377
Study Section
Special Emphasis Panel (ZRR1-RI-8 (02))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
9
Fiscal Year
2008
Total Cost
$219,017
Indirect Cost

  Institution

Name
University of Louisville
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Kuypers, Nicholas J; Bankston, Andrew N; Howard, Russell M et al. (2016) Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation. J Neurosci 36:1698-710
Myers, Scott A; Bankston, Andrew N; Burke, Darlene A et al. (2016) Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials? Exp Neurol 283:560-72
Ward, P J; Herrity, A N; Harkema, S J et al. (2016) Training-Induced Functional Gains following SCI. Neural Plast 2016:4307694
May, Zacnicte; Fouad, Karim; Shum-Siu, Alice et al. (2015) Challenges of animal models in SCI research: Effects of pre-injury task-specific training in adult rats before lesion. Behav Brain Res 291:26-35
Jagadapillai, Rekha; Mellen, Nicholas M; Sachleben Jr, Leroy R et al. (2014) Ceftriaxone preserves glutamate transporters and prevents intermittent hypoxia-induced vulnerability to brain excitotoxic injury. PLoS One 9:e100230
Nielson, Jessica L; Guandique, Cristian F; Liu, Aiwen W et al. (2014) Development of a database for translational spinal cord injury research. J Neurotrauma 31:1789-99
Ward, Patricia J; Herrity, April N; Smith, Rebecca R et al. (2014) Novel multi-system functional gains via task specific training in spinal cord injured male rats. J Neurotrauma 31:819-33
Ohri, Sujata Saraswat; Hetman, Michal; Whittemore, Scott R (2013) Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury. Neurobiol Dis 58:29-37
Kuypers, Nicholas J; James, Kurtis T; Enzmann, Gaby U et al. (2013) Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord. Exp Neurol 247:615-22
Schultz, R L; Kullman, E L; Waters, R P et al. (2013) Metabolic adaptations of skeletal muscle to voluntary wheel running exercise in hypertensive heart failure rats. Physiol Res 62:361-9

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