Abstract

EXCEED THE SPACEPROVIDED.Scientific research conducted in a Culture of Mentoring is fortified vastly with respect to both qualityandproductivity. This culture, which is being actively cultivated at the Oklahoma Medical Research Foundation,has played a vital role in the generation of numerous innovative and fundamentallyimportant biomedicalresearch breakthroughs credited to this Institution. Recognizing the important role of this culture instrengthening the research infrastructureat the OMRF and connected research environments, we describe inthis proposal a mechanism by which we seek to formalizeand stratify the mentoring process at OMRF, withthe goal of creating a self-sustaining system designed to maximize both individual and collective researchpotential. Within the context of this mission we seek to: 1) integrate and diversify individual and Programresearch efforts with the aim of achieving specific research objectives in the areas of immunology andneurobiology, and 2) strengthen individual and collective research efforts by reinforcing selected CoreResearch Facilities.The cumulative impact of these aims is the cultivation of a strong, supportive, and thoroughly progressiveresearch environment at OMRF, which functionsboth directly and indirectly to reinforce and energizebiomedical research here and throughout the state of Oklahoma.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015577-09
Application #
7417568
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Sayre, Michael
Project Start
2000-09-30
Project End
2010-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
9
Fiscal Year
2008
Total Cost
$1,820,108
Indirect Cost

  Institution

Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104

  Publications

Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2018) Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis. Sci Rep 8:7805
Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2016) Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis. Sci Rep 6:27453
Molineros, Julio E; Maiti, Amit K; Sun, Celi et al. (2013) Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet 9:e1003222
Smith, Kenneth; Muther, Jennifer J; Duke, Angie L et al. (2013) Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax®23 are serotype specific and facilitate opsonophagocytosis. Immunobiology 218:745-54
Dozmorov, Igor; Dominguez, Nicolas; Sestak, Andrea L et al. (2013) Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients. PLoS One 8:e71397
Jiang, Kaiyu; Frank, Mark; Chen, Yanmin et al. (2013) Genomic characterization of remission in juvenile idiopathic arthritis. Arthritis Res Ther 15:R100
Kurien, Biji T; D'Sousa, Anil; Bruner, Benjamin F et al. (2013) Prolidase deficiency breaks tolerance to lupus-associated antigens. Int J Rheum Dis 16:674-80
Vaughn, Samuel E; Kottyan, Leah C; Munroe, Melissa E et al. (2012) Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. J Leukoc Biol 92:577-91
Gaddy, Jasmine R; Vista, Evan S; Robertson, Julie M et al. (2012) Rheumatic disease among Oklahoma tribal populations: a cross-sectional study. J Rheumatol 39:1934-41
Hughes, Travis; Adler, Adam; Merrill, Joan T et al. (2012) Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-9

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