This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project has two complementary goals: 1) the identification of the cis-regulatory modules of gonad specific promoter regulatory elements; and 2) improvements of statistical technology for the identification of such modules. To these ends, we will apply Bayesian statistical inference methods to identify genes whose level of expression are altered as a direct result of changes in the levels of TAF4b and we will enhance our current algorithms, based on Gibbs sampling, with a model of the phylogenetic relationship among genes from related species. In addition, we will update the algorithm with an enhanced model of the spatial distribution among sites; an improved method for detection of short cis-binding patterns; a higher order model for the background portions of sequence data; and a method for the clustering of motif models to improve convergence.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015578-09
Application #
7720320
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2008-03-01
Project End
2009-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
9
Fiscal Year
2008
Total Cost
$53,547
Indirect Cost
Name
Brown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Lovasco, Lindsay A; Gustafson, Eric A; Seymour, Kimberly A et al. (2015) TAF4b is required for mouse spermatogonial stem cell development. Stem Cells 33:1267-76
Ribeiro, Jennifer R; Freiman, Richard N (2014) Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer. J Steroid Biochem Mol Biol 143:160-73
Casella, Cinzia; Miller, Daniel H; Lynch, Kerry et al. (2014) Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. Gynecol Oncol 135:333-41
Grive, Kathryn J; Seymour, Kimberly A; Mehta, Rajvi et al. (2014) TAF4b promotes mouse primordial follicle assembly and oocyte survival. Dev Biol 392:42-51
Tomimaru, Yoshito; Xu, Chelsea Q; Nambotin, Sarah B et al. (2013) Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity. Liver Int 33:1536-48
Minhas, Hassan M; Pescosolido, Matthew F; Schwede, Matthew et al. (2013) An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. Am J Med Genet A 161A:787-91
De Cecco, Marco; Criscione, Steven W; Peckham, Edward J et al. (2013) Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell 12:247-56
Li, Hua; Jogl, Gerwald (2013) Crystal structure of decaprenylphosphoryl-?- D-ribose 2'-epimerase from Mycobacterium smegmatis. Proteins 81:538-43
Tomimaru, Yoshito; Koga, Hironori; Yano, Hirohisa et al. (2013) Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. Liver Int 33:1100-12
Tomimaru, Yoshito; Koga, Hironori; Shin, Tai Ho et al. (2013) The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/?-catenin signal activation in hepatocellular carcinoma cells. Cancer Lett 336:359-69

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