EXCEED THE SPACEPROVIDED.The study of acquired and inherited human diseases has provided new insights into the role of ion channelmutations in a wide variety of human diseases (ion channelopathies). Although defects in anion (chloride)channels have been definitively linked to human diseases such as cystic fibrosis, generalized myotonias,and Batter Syndrome, the possible role of ion channelopathies in cardiovascular disease has been mostlylimited to the consideration of cation channel defects, and the role of anion channels in many types ofcardiovascular disease has not yet been systematically investigated. A major objective of this Center ofBiomedical Research Excellence (COBRE) is to advance our present understanding of the molecular andbiophysical properties of anion channels and their regulation in the cardiovascular'system, and determinetheir role in cardiovascular disease, using complementary experimental approaches that include well-definedanimal disease models, transgenic mice, molecular biology and genetics, electrophysiology, biomedicalimaging and functional genomics and proteomics. This competitive continuation application for COBREprogram support represents a comprehensive, multidisciplinary effort involving the coordination andintegration of five separate, but closely related, research projects, supported by three core facilities and anadministrative/ mentoring core. This COBRE program offers a variety of unique opportunities: (1) to advanceknowledge regarding the role of anion channelopathies in cardiovascular disease, (2) to support andpromote the development of a cadre of young, competitive biomedical research investigators at theUniversity of Nevada, (3) to promote the development of new, state-of-the-art transgenic, genomic,proteomic and molecular genetic resources at the University of Nevada School of Medicine (UNSOM).The long term objective of this NCRR-supported Center is to eventually transition this program into aCardiovascular Research Center at UNSOM supported by a NHLBI Program Project Grant.
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