This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. By facilitating the building of our personnel and infrastructure bases, COBRE support over the past five years has had a significant impact on research in microbial pathogenesis at the University of Idaho. In addition to two new COBRE-funded investigators added during the initial funding period, our university administration has partnered with the COBRE PI to create four additional tenure-track positions during the past four years. With this new group of talented faculty and the success of our COBRE faculty we have made progress toward establishing the UI as an institution with a nationally recognized biomedical program with a focus on microbial pathogenesis. To build upon this success, we propose four specific aims.
Specific Aim 1 : Extend the critical mass and expand the scientific diversity of the core group of COBRE co-Investigators. In this aim we propose to add to our existing COBRE team by providing research support for the recently hired faculty members, as well as more established faculty members not currently funded by NIH, and an additional person to be identified.
Specific Aim 2 : Expand and support COBRE funded core facilities. With COBRE and UI support, we were able to leverage private funding to build several state-of-the-art core facilities, including Structural Biology, Microscopy, Cell Separation, and Genomics Core Facilities. In this proposal, we describe plans to expand and/or support these facilities to ensure that initial investments made by COBRE and the UI efficiently enhance research of COBRE investigators and other biomedical investigators on campus.
Specific Aim 3 : Enhance the quality and numbers of graduate/medical students to participate in biomedical research. With the documented increase in higher quality graduate students we have been able to recruit since the beginning of the COBRE funding cycle, we will use additional COBRE funds to further enhance our graduate recruiting efforts. This will be done by enhancing stipends, promoting recruitment in the U.S. and internationally, plus interfacing with the Idaho INBRE's """"""""Pipeline to Graduate Education"""""""" program.
Specific Aim 4 : Transition toward self-sustaining biomedical research support from the National Institutes of Health following completion of COBRE funds.
This final aim will help to establish the COBRE investigators as independent researchers with the ultimate goal of obtaining long-term program project support from the NIH.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015587-10
Application #
7959724
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
10
Fiscal Year
2009
Total Cost
$723,813
Indirect Cost
Name
University of Idaho
Department
Microbiology/Immun/Virology
Type
Schools of Earth Sciences/Natur
DUNS #
075746271
City
Moscow
State
ID
Country
United States
Zip Code
83844
Kuan, Man I; O'Dowd, John M; Fortunato, Elizabeth A (2016) The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress. Virology 497:262-278
Zavala, Anamaria G; O'Dowd, John M; Fortunato, Elizabeth A (2016) Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function. J Virol 90:2523-35
Kuan, Man I; O'Dowd, John M; Chughtai, Kamila et al. (2016) Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53. Virology 497:279-293
Spencer, Simon E F; Besser, Thomas E; Cobbold, Rowland N et al. (2015) 'Super' or just 'above average'? Supershedders and the transmission of Escherichia coli O157:H7 among feedlot cattle. J R Soc Interface 12:0446
Bryant, Amy E; Bayer, Clifford R; Aldape, Michael J et al. (2015) The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections. Curr Opin Infect Dis 28:231-9
Kudva, Indira T; Krastins, Bryan; Torres, Alfredo G et al. (2015) The Escherichia coli O157:H7 cattle immunoproteome includes outer membrane protein A (OmpA), a modulator of adherence to bovine rectoanal junction squamous epithelial (RSE) cells. Proteomics 15:1829-42
Kulkarni, Amit S; Fortunato, Elizabeth A (2014) Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72. Viruses 6:968-85
Duan, Ying-Liang; Ye, Han-Qing; Zavala, Anamaria G et al. (2014) Maintenance of large numbers of virus genomes in human cytomegalovirus-infected T98G glioblastoma cells. J Virol 88:3861-73
Zavala, Anamaria G; Kulkarni, Amit S; Fortunato, Elizabeth A (2014) A dual color Southern blot to visualize two genomes or genic regions simultaneously. J Virol Methods 198:64-8
Czaja, Wioletta; Miller, Karen Y; Skinner, Michael K et al. (2014) Structural and functional conservation of fungal MatA and human SRY sex-determining proteins. Nat Commun 5:5434

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