This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific aim 1 is to characterize the ICH core, its surround and remote, functionally related regions of the brain during the hyperacute ( less than 1 hr) to acute (1-24 hrs) phases in the in vivo piglet model using magnetoencephalography (MEG), electrocorticography (EcoG), and intracortical field potential recordings. Thus, the SEPs from the various somatsosensory are prior to this time point are to be investigated. Hypothesis: Based on the literature, the SEPs are slightly larger in amplitude in the contralesional hemisphere, while the SEPs on the ipsilesinal side is reduced in amplitude during the hyperacute and acute periods.
Specific aim 2 is to characterize the ICH core, its surround and remote, functionally related regions of the brain at several time points during the subacute (1-7 days post ICH) and chronic (7-21 days) phases in a chronic piglet preparation using MEG and surface EEG. An experiment followed by euthanasia will be performed at one of the five time points, depending on the animal, to compare the location and type of abnormality inferred with non-invasive MEG and EEG to those determined with invasive EcoG and intracortical potential recordings.
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