This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching aim of the original proposal was to characterize the interictal and ictal generators of epileptic activity in humans. We hypothesized that areas of electrophysiologic abnormality corresponds to regions of metabolic abnormality or neuronal loss. Magnetoencephalography (MEG) and electroencephalography (EEG) would localize areas showing spike discharges. Proton magnetic resonance spectroscopy (1H-MRS) or magnetic resonance spectroscopic imaging (MRSI) will detect regions of metabolic abnormality or neuronal loss. Concomitantly, we performed MEG simulation studies to characterize how the anatomic variability of the frontal and temporal lobes affects spike initiation and propagation.
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