We will establish a center to promotethe study of cardiovascular diseases in South Carolina. Our COBRE focus oncardiovascular disease is significant because the citizens of our state aremore prone to cardiovascular disease than anywhere else in the nation. Forthis reason, the two medical schools in the state have united to develop theSouth Carolina COBRE on Cardiovascular Disease. This COME will significantlyaugment joint efforts in South Carolina to recruit, train and retain acritical mass of investigators with multidisciplinary skills and adequateinfrastructure to: (1) collaborate effectively in fundamental mechanisticstudies of cardiovascular diseases, and (2) compete successfully at thenational level for NIH and other merit-reviewed funding required to supportand extend their research endeavors. Five scientific projects proposed bytalented, newly recruited tenure-track faculty from five differentdepartments, three high tech scientific cores (transgenics, imaging,microarray/proteomics) directed by outstanding investigators with proven trackrecords in their area of expertise and an administrative/mentoring corecomprise the proposed center. The overarching theme is that cardiovasculardiseases derive from final common pathogenic pathways: proliferation,remodeling, apoptosis, transdifferentiation and vasculogenesis, each of whichis the focus of one or more projects. While the thematic focus iscardiovascular, the operant theme for implementation is mentoring. In statesthat are less competitive for research funding at the national level,effective mentoring of new investigators is an essential element of a researchdevelopment plan. This proposal addresses this need directly by: (1) pairingtargeted investigators with established NIH-funded researchers who haveexceptional mentoring track records as well as relevant critical expertise;(2) developing structured activities for skills acquisition and enhancement,such as seminars, journal clubs, retreats and special courses; (3)guaranteeing access to essential core resources with sufficient scientificexpertise and technical support to optimize their use; and (4) implementing aregular schedule (checkpoints) of progress reports and evaluation withcritical assistance from an External Advisory Committee of nationallyrecognized scientists.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016434-05
Application #
7170469
Study Section
Special Emphasis Panel (ZRR1-RI-A (01))
Project Start
2005-07-01
Project End
2006-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
5
Fiscal Year
2005
Total Cost
$103,970
Indirect Cost
Name
Medical University of South Carolina
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Soiberman, Uri; Foster, James W; Jun, Albert S et al. (2017) Pathophysiology of Keratoconus: What Do We Know Today. Open Ophthalmol J 11:252-261
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Moreno-Rodriguez, Ricardo A; Krug, Edward L; Reyes, Leticia et al. (2017) Linear array of multi-substrate tracts for simultaneous assessment of cell adhesion, migration, and differentiation. Biotechniques 63:267-274
Liu, Gang; Cooley, Marion A; Jarnicki, Andrew G et al. (2016) Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight 1:
Menon, Vinal; Junor, Lorain; Balhaj, Marwa et al. (2016) A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System. J Vis Exp :
Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell et al. (2016) Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn 245:1029-42
Olsen, T R; Mattix, B; Casco, M et al. (2015) Manipulation of cellular spheroid composition and the effects on vascular tissue fusion. Acta Biomater 13:188-98
Stevens, Shawn M; Brown, LaShardai N; Ezell, Paula C et al. (2015) The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration. J Vis Exp :
Menon, Vinal; Eberth, John F; Goodwin, Richard L et al. (2015) Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development. J Cardiovasc Dev Dis 2:108-124
Dupuis, Loren E; Berger, Matthew G; Feldman, Samuel et al. (2015) Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol 84:70-80

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