This application represents the competitive renewal for support of the Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM).
Specific aims of this proposal are:
Specific Aim 1 : Further develop the research and intellectual infrastructure of the University-wide Center for Neuroscience Excellence at UVM. Goals of this aim include 1) to continue a mentoring program for junior neuroscience faculty, 2) to maintain an imaging/physiology Core and a cellular/molecular Core to support the research projects of the neuroscience community, 3) to support a University-wide Neuroscience Seminar Series and Annual Retreat, and 4) to facilitate dialogue between basic and clinical scientists that promotes development of collaborative and translational research.
Specific Aim 2 : Support the research development of a Core group of junior faculty who will be future leaders in the Center for Neuroscience Excellence. The faculty and their project titles are 1) Dr. Alan Howe: Spatial Regulation of Protein Kinase A Signaling During Growth Cone Guidance, 2) Dr. Miguel Martin-Caraballo: Developmental regulation of GluR2 AMPA receptor subunit expression, 3) Dr. Jeffrey Spees: Adult Bone Marrow Stem Cells For CMS Repair, and 4) Dr. Umadevi Wesley: Role of Dipeptidyl Peptidase IV (DPPIV) in Peripheral Neurogenesis and Neuroblastomas. UVM has established investigators in molecular/developmental, cellular/systems and clinical/behavioral neuroscience. The current COBRE in Neuroscience provided a highly successful mechanism to significantly expand research strength in these existing areas, to integrate basic with clinical neuroscience, to create a long term mentoring framework for junior faculty and to develop a new university-wide Neuroscience Graduate Program. A goal of the next grant cycle is to build upon our success and develop a cohesive group of talented junior and senior investigators focused on neuronal development and differentiation that will form the Core for future applications directed at strategies to prevent and treat neurologic disease. UVM is the only doctoral degree granting institution in a state with limited resources due to its tax base of fewer than 625,000 people. The current COBRE funding has been instrumental in developing an excellent research infrastructure for neuroscience that has allowed the UVM neuroscience community to compete successfully for both significant new institutional funds and extramural support. Continued support of the Neuroscience COBRE by the National Center for Research Resources over the next funding cycle will ensure a return on investment that will benefit the University, the State of Vermont, the national research enterprise, and the patients looking to science for answers and hope. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016435-08
Application #
7477507
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Liu, Yanping
Project Start
2001-09-30
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$2,137,958
Indirect Cost
Name
University of Vermont & St Agric College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Schmoker, Anna M; Driscoll, Heather E; Geiger, Stefanie R et al. (2018) An in silico proteomics screen to predict and prioritize protein-protein interactions dependent on post-translationally modified motifs. Bioinformatics 34:3898-3906
St Clair, Riley M; Emerson, Sarah E; D'Elia, Kristen P et al. (2018) Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. FEBS J 285:72-86
Spear, E T; Holt, E A; Joyce, E J et al. (2018) Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Neurogastroenterol Motil 30:e13349
Schmoker, Anna M; Weinert, Jaye L; Kellett, Kyle J et al. (2017) Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2. Biochem J 474:3963-3984
Jacobs, Jesse V; Lyman, Courtney A; Hitt, Juvena R et al. (2017) Task-related and person-related variables influence the effect of low back pain on anticipatory postural adjustments. Hum Mov Sci 54:210-219
Villalba, Nuria; Sackheim, Adrian M; Nunez, Ivette A et al. (2017) Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase. J Neurotrauma 34:192-203
Fani, Negar; King, Tricia Z; Shin, Jaemin et al. (2016) STRUCTURAL AND FUNCTIONAL CONNECTIVITY IN POSTTRAUMATIC STRESS DISORDER: ASSOCIATIONS WITH FKBP5. Depress Anxiety 33:300-7
Clason, Todd A; Girard, Beatrice M; May, Victor et al. (2016) Activation of MEK/ERK Signaling by PACAP in Guinea Pig Cardiac Neurons. J Mol Neurosci 59:309-16
Jacobs, Jesse V; Roy, Carrie L; Hitt, Juvena R et al. (2016) Neural mechanisms and functional correlates of altered postural responses to perturbed standing balance with chronic low back pain. Neuroscience 339:511-524
Spohn, Stephanie N; Bianco, Francesca; Scott, Rachel B et al. (2016) Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon. Gastroenterology 151:933-944.e3

Showing the most recent 10 out of 219 publications