This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Administrative Core, primarily located at Dartmouth Medical School (DMS), will provide advising and mentoring, financial management, secretarial, and computer support for the entire COBRE Program. In the COBRE's fifth year of funding, Dr. Green, as P.I. of the overall COBRE program, has continued to provided research leadership and administrative skills, the latter via directing Administrative Core A. The project and core leaders are interacting in a productive manner under his guidance. The mentoring of the junior faculty occurs by the close involvement of Dr. Green and the established co-investigator/senior mentors, who have implemented a mentoring and assessment of progress structure for the career development of the COBRE project leaders. This assessment of progress includes expectations for publications, presentations, and additional extramural grant support. In this way the goal is to foster the independence and career development of each of the project leaders. The institutional commitment (Dartmouth and UNH) is evident by the important new faculty recruitments completed and underway, specifically the successful recruitments of the first four plus years, who have now established their research programs and thereby have provided additional scientific interactions to the COBRE investigative group. The COBRE interactions between Dartmouth and UNH are coordinated by the dialogue between Dr. Green and Dr. Trumble at their respective sites. As an example of these interactions, Drs. Green and Guyre of DMS have taken part in the work of the recent past UNH recruitments to focus on joint efforts under the COBRE. In addition, a junior faculty member of the COBRE group at UNH, Dr. Lisa Clark, who formerly trained as a Ph.D. graduate student at DMS, will help to coordinate existing activities and create new venues for interaction between the two campuses with Dr. Guyre at DMS. In addition, Dr. Clark has been awarded a Pilot Project to fund her work on leucine-rich repeat (LRR) structures and their ligands in the context of Toll-like receptors and other leukocyte cell-surface structures. This study is a collaborative effort with COBRE Project Leaders Drs. Berwin and Lang at DMS.
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