This application seeks support to establish a BRIN between six Maine institutions, with the MDIBL serving as the lead institution. The overall goal of this application is to develop a collaborative partnership and strong network composed of two premiere research institutions, the MDIBL and the Jackson Laboratory (JL); two undergraduate and graduate degree granting institutions, the University of Maine (UM) and the College of the Atlantic (COA); and two undergraduate degree-granting institutions: Bates College and Colby College. These six institutions will form a network for research training of faculty and students that will be advantageous by virtue of the quality and geographic proximity of the institutions involved. The scientific focus of the BRIN is comparative functional genomics. The principal hypothesis is that comparisons of sequence and function of genes between aquatic species, murine species and man will provide new insights into the mechanistic interactions between environmental stressors and human tissues, and the genetic basis for disease susceptibility. This network addresses the statewide need to enhance the biomedical research capacity and competitiveness of students and faculty in Maine by: 1) facilitating the networking of high-quality biomedical research institutions with undergraduate and graduate degree granting institutions; 2) providing training, education and mentoring of undergraduate and graduate students, as well as junior faculty in biomedical research; and 3) stimulating the year-round biomedical research program at MDIBL and basic science research by faculty at four undergraduate colleges. Maine's biomedical research capacity will be strengthened by an increase in research training opportunities at all participating institutions, and by an increase in the year-round presence of NIH-funded investigators at MDIBL. This BRIN will also aid in training and recruitment of qualified students for a new cooperative Ph.D. program in Molecular Genetics at UM, which has a commitment of participation from JL and MDIBL as of January 1, 2001. As faculty and students from participating academic institutions become better trained in biomedical research, there should be a greater number of successful competitive NIH research grant applications from these institutions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016463-03
Application #
6661996
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Program Officer
Blumsack, Martin B
Project Start
2001-09-30
Project End
2004-06-30
Budget Start
2003-09-01
Budget End
2004-06-30
Support Year
3
Fiscal Year
2003
Total Cost
$3,549,667
Indirect Cost
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salisbury Cove
State
ME
Country
United States
Zip Code
04672
Ariyachet, Chaiyaboot; Beißel, Christian; Li, Xiang et al. (2017) Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1. Mol Microbiol 104:499-519
Hahn, Mark E; Karchner, Sibel I; Merson, Rebeka R (2017) Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution. Curr Opin Toxicol 2:58-71
Nickerson, Chelsea A; Brown, Alexandra L; Yu, Waylin et al. (2017) Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats. Neuroscience 361:116-128
Palopoli, Michael F; Tra, Van; Matoin, Kassey et al. (2017) Evolution of host range in the follicle mite Demodex kutzeri. Parasitology 144:594-600
Mangiamele, Lisa A; Gomez, Julia R; Curtis, Nancy J et al. (2017) GPER/GPR30, a membrane estrogen receptor, is expressed in the brain and retina of a social fish (Carassius auratus) and colocalizes with isotocin. J Comp Neurol 525:252-270
Wirth, Peter; Yu, Waylin; Kimball, Amanda L et al. (2017) New method to induce mild traumatic brain injury in rodents produces differential outcomes in female and male Sprague Dawley rats. J Neurosci Methods 290:133-144
Christie, Andrew E; Roncalli, Vittoria; Cieslak, Matthew C et al. (2017) Prediction of a neuropeptidome for the eyestalk ganglia of the lobster Homarus americanus using a tissue-specific de novo assembled transcriptome. Gen Comp Endocrinol 243:96-119
Dickinson, Patsy S; Qu, Xuan; Stanhope, Meredith E (2016) Neuropeptide modulation of pattern-generating systems in crustaceans: comparative studies and approaches. Curr Opin Neurobiol 41:149-157
Dickinson, Patsy S; Calkins, Andrew; Stevens, Jake S (2015) Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus. J Neurophysiol 113:856-70
Palopoli, Michael F; Peden, Colin; Woo, Caitlin et al. (2015) Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes. BMC Evol Biol 15:93

Showing the most recent 10 out of 246 publications