This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
The aim of this pilot project is to investigate rhythmic patterns of innate immune system cell activity in zebrafish (Danio rerio). There is increasing evidence that components of the immune system are under circadian clock gene control, but the extent to which different white blood cell populations and their activities are influenced is far from clear. Zebrafish are a well-characterized vertebrate model and the existence of clock mutant strains makes them ideal for this study. Methods used to detect daily patterns of innate immune system activity include respiratory burst and phagocytosis assays, and cell cycle analysis.
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