This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.1) Projects currently in progressMy Ph.D. student Richard Bernhardt and I have been studying effects of perchlorate on stickleback fish for the past five years. So far, we have published an analytical chemistry methods paper with three colleagues1, and a paper with William Cresko of the University of Oregon demonstrating that perchlorate causes genetically-female stickleback to develop into functional hermaphrodites, and genetically-male fish to develop super large testes2. This manuscript, which was published in August, 2006, also demonstrates that perchlorate interferes with the expression of normal nuptial coloration and reduces survivorship. This study provides the first evidence that perchlorate causes masculinization and is capable of inducing functional hermaphroditism in a nonhermaphroditic vertebrate. Because of these findings, the study received significant media coverage3,4,5.2) Objectives and goals for grant fiscal year starting May 2007We plan to begin a two-year stickleback experiment in my lab this May with six treatment groups: control (background), 10 ppb, 50 ppb, 500 ppb, 3,000 ppb, and 30,000 ppb (30,000 corresponds to our experimental level of 30 ppm where we observed hermaphroditism in female stickleback). The stickleback reproductive season begins in May and ends in July, so we plan to have our experimental set up complete by late April. I have requested funds from INBRE to build the experimental set-up this winter.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016466-08
Application #
7719968
Study Section
Special Emphasis Panel (ZRR1-RI-7 (02))
Project Start
2008-05-01
Project End
2009-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
8
Fiscal Year
2008
Total Cost
$32,206
Indirect Cost
Name
University of Alaska Fairbanks
Department
Type
Organized Research Units
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99775
Wilson, Robert E; Ely, Craig R; Talbot, Sandra L (2018) Flyway structure in the circumpolar greater white-fronted goose. Ecol Evol 8:8490-8507
Hueffer, Karsten; Khatri, Shailesh; Rideout, Shane et al. (2017) Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. Sci Rep 7:12818
Ely, Craig R; Wilson, Robert E; Talbot, Sandra L (2017) Genetic structure among greater white-fronted goose populations of the Pacific Flyway. Ecol Evol 7:2956-2968
Talbot, Sandra L; Sage, George K; Sonsthagen, Sarah A et al. (2017) Intraspecific evolutionary relationships among peregrine falcons in western North American high latitudes. PLoS One 12:e0188185
Leewis, Mary-Cathrine; Uhlik, Ondrej; Fraraccio, Serena et al. (2016) Differential Impacts of Willow and Mineral Fertilizer on Bacterial Communities and Biodegradation in Diesel Fuel Oil-Contaminated Soil. Front Microbiol 7:837
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Vayndorf, Elena M; Scerbak, Courtney; Hunter, Skyler et al. (2016) Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis. NPJ Aging Mech Dis 2:
Goldsmith, Elizabeth W; Renshaw, Benjamin; Clement, Christopher J et al. (2016) Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska. Mol Ecol 25:675-88
Leewis, Mary-Cathrine; Uhlik, Ondrej; Leigh, Mary Beth (2016) Synergistic Processing of Biphenyl and Benzoate: Carbon Flow Through the Bacterial Community in Polychlorinated-Biphenyl-Contaminated Soil. Sci Rep 6:22145

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