This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives of Proposed Research: 1. Calibrate tissue 15N enrichment to lean mass use in torpid S. parryii that are either thermoneutral (Ta = +2?C) or thermoregulating (Ta = -10?C). 2. Elucidate and quantify patterns of expression of key metabolic genes of torpid S. parryii that are either thermoneutral (+2?C) or thermoregulating (-10?C). 3. Describe the energetics, substrate selection and limits to hibernation at extreme low Ta. 4. Correlate pre-hibernation body condition and hibernacula temperatures to overwinter changes in body condition, phenology, stable isotope signatures and components to fitness in natural populations. Given the extreme plasticity of their metabolism and body temperature, hibernators have been adopted as a model species for a number of human disease and injury states, including heart disease, ischemia, Alzheimer's, and traumatic head injury. Thus, results from the laboratory portion of this research could have applied implications for biomedicine. Field studies will contribute significantly to understanding organismal responses to a changing arctic climate. Proposed work will address important questions in hibernation physiology with new, interdisciplinary approaches. It will contribute significantly to comparative physiology by establishing limits to hibernation eco-physiology and mechanisms that create these constraints;to stable isotope ecology by documenting tissue 15N enrichment in an extreme animal model of starvation;and to comparative genomics, by further developing the RT-PCR approach to transcriptomics in a new model organism for ecophysiology and biomedicine. The work will link unique physiological traits of S. parryii with field measurements of hibernacula temperatures to increase knowledge of adaptation to the Arctic, and will provide the power to predict how changes in global climate may affect the population dynamics of an important arctic species.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016466-09
Application #
7960097
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2009-05-01
Project End
2010-02-28
Budget Start
2009-05-01
Budget End
2010-02-28
Support Year
9
Fiscal Year
2009
Total Cost
$35,544
Indirect Cost
Name
University of Alaska Fairbanks
Department
Type
Organized Research Units
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99775
Wilson, Robert E; Ely, Craig R; Talbot, Sandra L (2018) Flyway structure in the circumpolar greater white-fronted goose. Ecol Evol 8:8490-8507
Hueffer, Karsten; Khatri, Shailesh; Rideout, Shane et al. (2017) Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. Sci Rep 7:12818
Ely, Craig R; Wilson, Robert E; Talbot, Sandra L (2017) Genetic structure among greater white-fronted goose populations of the Pacific Flyway. Ecol Evol 7:2956-2968
Talbot, Sandra L; Sage, George K; Sonsthagen, Sarah A et al. (2017) Intraspecific evolutionary relationships among peregrine falcons in western North American high latitudes. PLoS One 12:e0188185
Leewis, Mary-Cathrine; Uhlik, Ondrej; Fraraccio, Serena et al. (2016) Differential Impacts of Willow and Mineral Fertilizer on Bacterial Communities and Biodegradation in Diesel Fuel Oil-Contaminated Soil. Front Microbiol 7:837
Harley, John R; Bammler, Theo K; Farin, Federico M et al. (2016) Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research. Environ Sci Technol 50:1990-9
Hoffman, M; Taylor, B E; Harris, M B (2016) Evolution of lung breathing from a lungless primitive vertebrate. Respir Physiol Neurobiol 224:11-6
Vayndorf, Elena M; Scerbak, Courtney; Hunter, Skyler et al. (2016) Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis. NPJ Aging Mech Dis 2:
Goldsmith, Elizabeth W; Renshaw, Benjamin; Clement, Christopher J et al. (2016) Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska. Mol Ecol 25:675-88
Leewis, Mary-Cathrine; Uhlik, Ondrej; Leigh, Mary Beth (2016) Synergistic Processing of Biphenyl and Benzoate: Carbon Flow Through the Bacterial Community in Polychlorinated-Biphenyl-Contaminated Soil. Sci Rep 6:22145

Showing the most recent 10 out of 113 publications