Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Robert A. Sikes, Ph.D.Role of IGFBP-2 Fragments in Development of Androgen Insensitive Prostate CancerThis project was designed to 1) Isolate and obtain sequence information from IGFBP-2 fragments, 2) to clone the IGFBP-2 open reading frame into an expression vector where the ends are modified by adding small peptide tags, and 3) to introduce and express these constructs in CHO cells to obtain tagged recombinant IGFBP-2 to study proteolysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016472-08
Application #
7720252
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2008-05-01
Project End
2009-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
8
Fiscal Year
2008
Total Cost
$44,087
Indirect Cost

  Institution

Name
University of Delaware
Department
Type
Organized Research Units
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Wenner, Megan M; Paul, Erin P; Robinson, Austin T et al. (2018) Acute NaCl Loading Reveals a Higher Blood Pressure for a Given Serum Sodium Level in African American Compared to Caucasian Adults. Front Physiol 9:1354
Viswanathan, Vignesh; Damle, Shirish; Zhang, Tao et al. (2017) An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia. Cancer Res 77:3778-3790
Brewer-Smyth, Kathleen; Pohlig, Ryan T (2017) Risk Factors for Women Being Under the Influence of Alcohol Compared With Other Illicit Substances at the Time of Committing Violent Crimes. J Forensic Nurs 13:186-195
Liang, Yingkai; Li, Linqing; Scott, Rebecca A et al. (2017) Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry. Macromolecules 50:483-502
Freudenberg, Uwe; Liang, Yingkai; Kiick, Kristi L et al. (2016) Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Adv Mater 28:8861-8891
Marnocha, C L; Levy, A T; Powell, D H et al. (2016) Mechanisms of extracellular S0 globule production and degradation in Chlorobaculumtepidum via dynamic cell-globule interactions. Microbiology 162:1125-34
Boukari, Fatima; Makrogiannis, Sokratis; Nossal, Ralph et al. (2016) Imaging and tracking HIV viruses in human cervical mucus. J Biomed Opt 21:96001
Choi, Yong Seok; Lee, Kelvin H (2016) Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease. Arch Pharm Res 39:390-7
Brewer-Smyth, Kathleen; Pohlig, Ryan T; Bucurescu, Gabriel (2016) Female children with incarcerated adult family members at risk for lifelong neurological decline. Health Care Women Int 37:802-13
Audette, Dylan S; Anand, Deepti; So, Tammy et al. (2016) Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression. Development 143:318-28

Showing the most recent 10 out of 203 publications