Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Epithelial ovarian cancer is an ovulation-related disease. It appears that genotoxic/mutagenic reactive oxygen species generated during the mechanics of follicular rupture damage the DNA of ovarian surface epithelial cells that survive the insult of ovulation; a cell that is not repaired or does not become committed to apoptosis (because of a defective tumor suppressor mechanism) is hence potentially problematic. Since the prognosis for ovarian cancer patients with metastatic disease is so poor, and early detection has proven elusive, it is imperative that prospective methods of chemoprevention be explored. The objectives of this subproject are to assess the etiological link between ovulation and carcinogenesis and to evaluate the prospective role of antioxidants (e.g., vitamin E) in ovarian cancer prophylaxis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016474-06
Application #
7381593
Study Section
Special Emphasis Panel (ZRR1-RI-7 (02))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$166,895
Indirect Cost

  Institution

Name
University of Wyoming
Department
Type
Schools of Allied Health Profes
DUNS #
069690956
City
Laramie
State
WY
Country
United States
Zip Code
82071

  Publications

Corda, Erica; Du, Xiaotang; Shim, Su Yeon et al. (2018) Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes ?-Cleavage of PrPC. Mol Neurobiol 55:7758-7774
Lindblom, Stormy D; Wangeline, Ami L; Valdez Barillas, Jose R et al. (2018) Fungal Endophyte Alternaria tenuissima Can Affect Growth and Selenium Accumulation in Its Hyperaccumulator Host Astragalus bisulcatus. Front Plant Sci 9:1213
Zhang, Yingmei; Ren, Jun (2018) Corrigendum to ""Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation"" [Free Radic. Biol. Med. 51(12) (2011) 2172-2184]. Free Radic Biol Med 117:259-261
Jiang, Zhongliang; Jiang, Kun; McBride, Ralph et al. (2018) Comparative cytocompatibility of multiple candidate cell types to photoencapsulation in PEGNB/PEGDA macroscale or microscale hydrogels. Biomed Mater 13:065012
Jiang, Zhongliang; Xia, Bingzhao; McBride, Ralph et al. (2017) A microfluidic-based cell encapsulation platform to achieve high long-term cell viability in photopolymerized PEGNB hydrogel microspheres. J Mater Chem B 5:173-180
Young, Coleman H; Rothfuss, Heather M; Gard, Philip F et al. (2017) Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells. Reproduction 153:1-10
Wykes, Thomas L; Lee, Aaron A; Bourassa, Katelynn et al. (2017) Diabetes Knowledge Among Adults with Serious Mental Illness and Comorbid Diabetes Mellitus. Arch Psychiatr Nurs 31:190-196
Thomas, Jenifer J; Moring, John C; Harvey, Terra et al. (2016) Risk of type 2 diabetes: health care provider perceptions of prevention adherence. Appl Nurs Res 32:1-6
Edwards, Brian S; Dang, An K; Murtazina, Dilyara A et al. (2016) Dynamin Is Required for GnRH Signaling to L-Type Calcium Channels and Activation of ERK. Endocrinology 157:831-43
Kapali, Jyoti; Kabat, Brock E; Schmidt, Kelly L et al. (2016) Foxo1 Is Required for Normal Somatotrope Differentiation. Endocrinology 157:4351-4363

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