This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Our long-term goal is to gain a detailed understanding of the components, regulation, and biological functions of glycopeptide hormone signaling using the model organism C. elegans. Our well-developed findings have revealed several key reproductive functions for FSHR-1, the C. elegans ancestral ortholog of the FSH/LH/TSH receptor, including roles in the induction of oocyte development, maintenance of the germline stem cell population, and the promotion of germ cell survival through the inhibition of apoptosis. The goal of this project is to develop genetic approaches that can be used to identify the downstream and accessory components of FSHR-1 signaling. It is expected that studies in C. elegans will provide a potent and efficient means for uncovering conserved and novel factors that mediate the transduction of glycopeptide hormone signaling. Our broad knowledge of C. elegans developmental biology and genetics as well as our very extensive preliminary results, place us in an excellent position for the successful completion of our specific aims.
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