Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It is known that antioxidants from fruits and vegetables have protective effects against lung, colon, breast, prostate, bladder, and stomach cancer. In this study, we will investigate the roles of potential signaling pathways inhibited by apigenin and flavonoids in mediating ovarian cancer cell proliferation and tumor growth. The study will provide further insight into the molecular mechanism(s) underlying apigenin-mediated inhibition of ovarian tumor formation and angiogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016477-11
Application #
8360187
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
11
Fiscal Year
2011
Total Cost
$144,326
Indirect Cost

  Institution

Name
Marshall University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25701

  Publications

Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary compound proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits via targeting the Wnt/?-catenin signaling pathway and inducing G1 cell cycle arrest. Food Funct 9:525-533
Gao, Ying; Yin, Junfeng; Rankin, Gary O et al. (2018) Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells. Molecules 23:
Pan, Haibo; Li, Jin; Rankin, Gary O et al. (2018) Synergistic effect of black tea polyphenol, theaflavin-3,3'-digallate with cisplatin against cisplatin resistant human ovarian cancer cells. J Funct Foods 46:1-11
Zhang, Shichao; Xing, Malcolm M Q; Li, Bingyun (2018) Capsule Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery. ACS Appl Mater Interfaces :
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells. Eur J Med Chem 147:218-226
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary Compound Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves inhibit angiogenesis and regulate cell cycle of cisplatin-resistant ovarian cancer cells via targeting Akt pathway. J Funct Foods 40:573-581
Haramizu, Satoshi; Asano, Shinichi; Butler, David C et al. (2017) Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J Nutr Biochem 50:103-115
Jones, Brandon C; Kelley, Laura C; Loskutov, Yuriy V et al. (2017) Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior. Mol Cancer Res 15:670-682
Lemaster, Kent; Jackson, Dwayne; Welsh, Donald G et al. (2017) Altered distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in metabolic syndrome. Microcirculation 24:
He, Xiaoqing; Wang, Liying; Riedel, Heimo et al. (2017) Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells. Mol Cancer 16:63

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