Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Very little is known about the role of SG formation in controlling viral infection. It is known that SG form in both herpes and alphavirus infected cells. While these studies are intriguing, they did not address different viral strains, the affect of interferon on SG formation or the individual contribution of TIA-1 or TIA-R in SG formation. By using TIA-1 or TIA-R knockout cell lines we have preliminary data that TIA-R is not involved in the innate response against herpes simplex 1 (HSV1) whereas TIA-1 plays a critical role in limiting HSV1 production (i.e. viral titers for HSV1 are similar in both wild type cells and TIA-R-/- cells, but significantly higher in TIA-1-/- cells). Immune preciptations (IP) were performed to identify viral proteins that affect SG formation. To date no viral proteins have been identified.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016480-09
Application #
7960243
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2009-05-01
Project End
2010-02-28
Budget Start
2009-05-01
Budget End
2010-02-28
Support Year
9
Fiscal Year
2009
Total Cost
$64,373
Indirect Cost

  Institution

Name
New Mexico State University Las Cruces
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003

  Publications

Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934
Duplessis, Christopher; Gregory, Michael; Frey, Kenneth et al. (2018) Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis. J Intensive Care 6:72
Johnston, Robert K; Harper, Jason C; Tartis, Michaelann S (2017) Control over Silica Particle Growth and Particle-Biomolecule Interactions Facilitates Silica Encapsulation of Mammalian Cells with Thickness Control. ACS Biomater Sci Eng 3:2098-2109
Rossi, Shannan L; Tesh, Robert B; Azar, Sasha R et al. (2016) Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 94:1362-9
Shuster, Michele; Claussen, Kira; Locke, Melly et al. (2016) BIOINFORMATICS IN THE K-8 CLASSROOM: DESIGNING INNOVATIVE ACTIVITIES FOR TEACHER IMPLEMENTATION. Int J Des Learn 7:60-70
Tsalik, Ephraim L; Henao, Ricardo; Nichols, Marshall et al. (2016) Host gene expression classifiers diagnose acute respiratory illness etiology. Sci Transl Med 8:322ra11
Colip, Leslie; Burge, Mark R; Sandy, Phillip et al. (2016) Exercise Intervention Improves the Metabolic Profile and Body Composition of Southwestern American Indian Adolescents. J Diabetes Obes 3:
Reiss, Rebecca A; Guerra, Peter; Makhnin, Oleg (2016) Metagenome phylogenetic profiling of microbial community evolution in a tetrachloroethene-contaminated aquifer responding to enhanced reductive dechlorination protocols. Stand Genomic Sci 11:88
Camacho, Jenny E; Shah, Vallabh O; Schrader, Ronald et al. (2016) PERFORMANCE OF A1C VERSUS OGTT FOR THE DIAGNOSIS OF PREDIABETES IN A COMMUNITY-BASED SCREENING. Endocr Pract 22:1288-1295
Andrade, C C; Young, K I; Johnson, W L et al. (2016) Rise and fall of vector infectivity during sequential strain displacements by mosquito-borne dengue virus. J Evol Biol 29:2205-2218

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