Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Sub-Core advises on matters regarding animal care and use in the COBRE projects or pilot projects. Dr. John Harkness is the Animal Sub-Core director and is a board-certified (ACLAM) laboratory animal veterinarian. Activities of the Animal Sub-Core include advising on applicable regulatory matters, implementation of a stringent biosecurity program (based on consultation with Dr. Lauretta Gerrity of University of Alabama - Birmingham), continued operation of a sentinel program, routine husbandry and veterinary care, advice to project and pilot project directors concerning animal issues or manipulations, e.g., anesthesia and assistance with animal protocols, purchase and per diem charges, and direction of animal caretakers involved with the animals used in COBRE projects. In addition, animal numbers used on each of the COBRE projects are tracked by this sub-core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017661-05
Application #
7381811
Study Section
Special Emphasis Panel (ZRR1-RI-A (02))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2006
Total Cost
$30,307
Indirect Cost

  Institution

Name
Mississippi State University
Department
Public Health & Prev Medicine
Type
Schools of Veterinary Medicine
DUNS #
075461814
City
Mississippi State
State
MS
Country
United States
Zip Code
39762

  Publications

Hossain, Delwar; Pittman Jr, Charles U; Gwaltney, Steven R (2014) Structures and Stabilities of the Metal Doped Gold Nano-Clusters: M@Au10 (M = W, Mo, Ru, Co). J Inorg Organomet Polym Mater 24:241-249
Ross, Matthew K; Borazjani, Abdolsamad; Wang, Ran et al. (2012) Examination of the carboxylesterase phenotype in human liver. Arch Biochem Biophys 522:44-56
Yu, Xiaozhen; Sigler, Sara C; Hossain, Delwar et al. (2012) Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism. J Mol Model 18:2869-83
Carr, Russell L; Borazjani, Abdolsamad; Ross, Matthew K (2011) Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol Sci 122:112-20
Howell 3rd, George; Mangum, Lauren (2011) Exposure to bioaccumulative organochlorine compounds alters adipogenesis, fatty acid uptake, and adipokine production in NIH3T3-L1 cells. Toxicol In Vitro 25:394-402
Crow, J Allen; Herring, Katye L; Xie, Shuqi et al. (2010) Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Biochim Biophys Acta 1801:31-41
Eells, Jeffrey B; Brown, Timothy (2009) Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels. Neurotoxicol Teratol 31:98-103
Johnson, Frank O; Chambers, Janice E; Nail, Carole A et al. (2009) Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats. Toxicol Sci 109:132-42
Crow, J Allen; Middleton, Brandy L; Borazjani, Abdolsamad et al. (2008) Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages. Biochim Biophys Acta 1781:643-54
Dail, Mary B; Shack, L Allen; Chambers, Janice E et al. (2008) Global liver proteomics of rats exposed for 5 days to phenobarbital identifies changes associated with cancer and with CYP metabolism. Toxicol Sci 106:556-69

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