? The overall goals of the Nebraska Redox Biology Center are to (i) buttress and expand the existing strengths in redox biology in Nebraska by mentoring junior faculty to success, recruiting new faculty with complementary research interests and strategically enhancing biomedical research infrastructure; and (ii) create a nationally visible and internationally recognized Center that will be sustained beyond the duration of the COBRE grant by intra- and extra-mural sources of funding. The Center has initiated efforts necessary to realize its goals but faces a key specific impediment, viz, renovation of laboratory space that is essential for recruitment of a faculty member (in microbial pathogenesis) to the Department of Veterinary and Biomedical Sciences at the University of Nebraska- Lincoln. While this request for renovation was included in the original proposal, an oversight on the Pl's part led to provision of insufficient information regarding floor plans and budget justification, and resulted in the recommendation by the study section for its deletion from the final budget.
The specific aim of this application is to redress this deficiency by obtaining the requisite support for renovating and converting existing storage space in the Department of Veterinary and Biomedical Sciences at the University of Nebraska-Lincoln into laboratory space to enable recruitment of a faculty member in the area of microbial pathogenesis. The involvement of the Department of Veterinary and Biomedical Sciences in the future growth and success of the Nebraska Redox Biology Center is important, due in part to the active participation of two of its members in the Center's functions. Additionally, the proposed hire in microbial pathogenesis would not only complement the expertise of Center-associated faculty, but had been identified independently as the top priority in the strategic planning documents by the Department of Veterinary and Biomedical Sciences. ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
3P20RR017675-02S1
Application #
6707388
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Program Officer
Sayre, Michael
Project Start
2002-09-30
Project End
2004-06-30
Budget Start
2003-09-01
Budget End
2004-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$488,118
Indirect Cost
Name
University of Nebraska Lincoln
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68588
Garza-Lombó, Carla; Schroder, Annika; Reyes-Reyes, Elsa M et al. (2018) mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival. Curr Opin Toxicol 8:102-110
Marshall, Darrell D; Powers, Robert (2017) Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics. Prog Nucl Magn Reson Spectrosc 100:1-16
Anandhan, Annadurai; Lei, Shulei; Levytskyy, Roman et al. (2017) Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (?-Synuclein)-Environment (Paraquat) Interactions. Mol Neurobiol 54:3825-3842
Rose, Jordan; Brian, Christian; Woods, Jade et al. (2017) Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival. Toxicology 391:109-115
Boone, Cory H T; Grove, Ryan A; Adamcova, Dana et al. (2017) Oxidative stress, metabolomics profiling, and mechanism of local anesthetic induced cell death in yeast. Redox Biol 12:139-149
Markley, John L; Brüschweiler, Rafael; Edison, Arthur S et al. (2017) The future of NMR-based metabolomics. Curr Opin Biotechnol 43:34-40
Duszenko, Nikolas; Buan, Nicole R (2017) Physiological Evidence for Isopotential Tunneling in the Electron Transport Chain of Methane-Producing Archaea. Appl Environ Microbiol 83:
Anandhan, Annadurai; Jacome, Maria S; Lei, Shulei et al. (2017) Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism. Brain Res Bull 133:12-30
Gebregiworgis, Teklab; Nielsen, Helle H; Massilamany, Chandirasegaran et al. (2016) A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica. J Proteome Res 15:659-66
Navarro-Yepes, Juliana; Anandhan, Annadurai; Bradley, Erin et al. (2016) Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Mol Neurobiol 53:5229-51

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