The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of SC. This will be accomplished through the combined efforts of a number of investigators at the USC who have merged their collective expertise in formation of a multidisciplinary research group studying the biology of colorectal cancer, its therapy, and its prevention. Colorectal cancer is a leading cause of cancer death in the US, with about 150,000 new cases and 56,000 deaths occurring annually. Current pharmacologic regimens provide only marginal benefit in managing the disease, owing to the drug resistance of colorectal tumors, as well as to the toxic side-effects evoked by these regimens. The biomedical scientists who have come together for this application have formed an interdisciplinary center, the Center for Colon Cancer Research (CCCR) that has focused its efforts around the problem of colorectal cancer. The research proposed in the current COBRE application has three aims. The first is to carry out research on specific molecular, biochemical, genetic, and lifestyle factors that impact upon colorectal cancer and its therapy. This will be done by supporting four projects led by promising junior faculty members.
The second aim i s to provide core facilities in support of these research projects, giving the lead investigators necessary state-of-the-art technical capabilities.
The final aim i s to manage a program through which the four young faculty, as well as ten new faculty to be recruited during the five-year period of the grant, are mentored by established investigators with substantive records in NIH funding. In all, the COBRE program proposed in this application will have two long-tern1 benefits. First, the number of NIH-competitive researchers in SC will increase. Second, the CCCR will be poised to apply for a program project grant in the area of colon cancer. Such grants are few in SC and in other IdeA states.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017698-05
Application #
7124989
Study Section
Special Emphasis Panel (ZRR1-RI-A (02))
Program Officer
Gorospe, Rafael
Project Start
2002-09-29
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2006
Total Cost
$2,095,687
Indirect Cost
Name
University of South Carolina at Columbia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48
Montalvo, Ryan N; Hardee, Justin P; VanderVeen, Brandon N et al. (2018) Resistance Exercise's Ability to Reverse Cancer-Induced Anabolic Resistance. Exerc Sport Sci Rev 46:247-253
Eberth, Jan M; Thibault, Annie; Caldwell, Renay et al. (2018) A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 124:1912-1920
Mentrup, Heather L; Hartman, Amanda; Thames, Elizabeth L et al. (2018) The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration. Differentiation 99:51-61
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
Gao, Feng J; Shi, Liang; Hines, Timothy et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell 28:587-599
Hardee, Justin P; Montalvo, Ryan N; Carson, James A (2017) Linking Cancer Cachexia-Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism. Oxid Med Cell Longev 2017:8018197
Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2017) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal 37:716-732
Chumanevich, Anastasiya A; Chaparala, Anusha; Witalison, Erin E et al. (2017) Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds. Oncotarget 8:228-237
Oliver, David; Ji, Hao; Liu, Piaomu et al. (2017) Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep 7:43023

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