This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two new faculty, Drs. Wayne Outten and Caryn Outten have joined the USC faculty, and are investogators in our COBRE center. Both are tenure-track faculty in the Department of Chemistry & Biochemistry, and have been receiving COBRE funds to help startup their labs. Our junior faculty have been active in submitting grant applications this past year, and a number of successes have occurred. Drs. Smith and Muga each submitted application that did not receive funding. Dr. Smith received a percentile of 26.5, which is a strong score, though not strong enough for an award in this very difficult funding climate. Both Dr. Smith and Dr. Muga will be graduating from COBRE funding at the end of the current year, and are preparing revisions for the June/July cycle at the NIH. Dr. Dixon received a grant from the ACS to support his research on gene therapeutic approaches to regulating COX-2 expression. Dr. Hofseth received an R21 grant from the NIH, which involves analysis of the anti-inflammatory properties of gincko biloba in cancer prevention. Dr. Buckhaults just submitted grants to the ACS and the AACR focusing on molecular mechanisms of metastasis. He has plans for an NIH submission this summer. Dr. Carson is preparing a revised application for the July deadline, based on his studies of IL-6 as a mediator of cachexia and intestinal polyposis in ApcMin/+ mice. Dr. Burch received a VISN 7 Research Career Development Award from the Veteran's Administration. This will support his salary over two years of his startup phase of his career. In January, the COBRE group conducted a one-day retreat where all junior faculty presented their progress. In addition, proposals fro seed funding were presented, and several were chosen to be incorporated into the competitive renewal this August. In recognition of Colorectal Cancer Awareness Month in March, the COBRE center co-sponosoreed a one-day meeting in Spartanburg, SC, called 'Colorectal Cancer: From the Benches to the Trenches'. At this meeting were ~75 people, including scientists, clinicians, primary care physicians, epidemiologists, public health practitioners, policy experts, survivors, and advocates. This broad group of people with expertise in colorectal cancer listened to talks and dicussed a variety of issues related to this disease in SC. It was the first of what is to become an annual event, and it is hoped that by bringing together this kind of group, we can identify problems and barriers related to colorectal cancer screening ,education, treatment, and prevention in SC, and implement novel strategies to address them. Ms. Anjee Davis, our COBRE center's Administrative Manager, was a central organizer of this meeting.
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