Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Dr. Buckhaults will characterize specific genetic changes in human colorectal tumors that are associated with metastatic disease. He has recently shown, using a digital genotyping assay, that loss-of-heterozygosity (LOH) at human chromosome 8p is associated with a node-positive phenotype. Following up on this important discovery, he will conduct further LOH analysis to define the minimal region of 8p associated with node status. Using gene expression profiling and DNA sequence analysis, he will attempt to identify the single gene that is mutated in node-positive colorectal tumors. These efforts will provide prognostic tools to specifically address metastatic forms of colorectal cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR017698-06
Application #
7610473
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2007-08-01
Project End
2008-05-31
Budget Start
2007-08-01
Budget End
2008-05-31
Support Year
6
Fiscal Year
2007
Total Cost
$164,319
Indirect Cost

  Institution

Name
University of South Carolina at Columbia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208

  Publications

Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48
Montalvo, Ryan N; Hardee, Justin P; VanderVeen, Brandon N et al. (2018) Resistance Exercise's Ability to Reverse Cancer-Induced Anabolic Resistance. Exerc Sport Sci Rev 46:247-253
Eberth, Jan M; Thibault, Annie; Caldwell, Renay et al. (2018) A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 124:1912-1920
Mentrup, Heather L; Hartman, Amanda; Thames, Elizabeth L et al. (2018) The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration. Differentiation 99:51-61
Oliver, David; Ji, Hao; Liu, Piaomu et al. (2017) Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep 7:43023
Alexander, M; Burch, J B; Steck, S E et al. (2017) Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis 32:183-192
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
Gao, Feng J; Shi, Liang; Hines, Timothy et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell 28:587-599
Hardee, Justin P; Montalvo, Ryan N; Carson, James A (2017) Linking Cancer Cachexia-Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism. Oxid Med Cell Longev 2017:8018197
Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2017) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal 37:716-732

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