Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The major hypothesis of the research proposal is that selective expression of Tat in NPCs may alter the proliferation, differentiation and survival of NPCs in the CNS, which may lead to neurocognitive dysfunction, similar to HIV-1-mediated HAD. The following aims will be performed to test the hypothesis: 1) To establish a mouse model of selective expression of HIV-1 Tat protein in NPCs, and to study the effect of Tat expression on NPC proliferation, differentiation and survival. 2) To study and validate the effects of Tat expression in NPCs on neurocognitive function (dysfunction) in the transgenic mouse model recapitulating HIV-1-mediated HAD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017699-07
Application #
7720893
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
7
Fiscal Year
2008
Total Cost
$39,646
Indirect Cost

  Institution

Name
University of North Dakota
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202

  Publications

Kulas, Joshua A; Puig, Kendra L; Combs, Colin K (2017) Amyloid precursor protein in pancreatic islets. J Endocrinol 235:49-67
Krout, Danielle; Pramod, Akula Bala; Dahal, Rejwi Acharya et al. (2017) Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochem Pharmacol 142:204-215
Sukumaran, Pramod; Schaar, Anne; Sun, Yuyang et al. (2016) Functional role of TRP channels in modulating ER stress and Autophagy. Cell Calcium 60:123-32
Puig, Kendra L; Kulas, Joshua A; Franklin, Whitney et al. (2016) The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice. Neurobiol Aging 40:22-40
Liu, Qing Yan; Koukiekolo, Roger; Zhang, Dong Ling et al. (2016) Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model. Am J Neurodegener Dis 5:74-84
Moritz, Amy E; Rastedt, Danielle E; Stanislowski, Daniel J et al. (2015) Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. J Biol Chem 290:29095-105
Zhou, Xikun; Ye, Yan; Sun, Yuyang et al. (2015) Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase C? Signaling. Mol Cell Biol 35:2729-39
Zhang, Shuang; Yu, Min; Guo, Qiang et al. (2015) Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway. Sci Rep 5:15859
Puig, Kendra L; Lutz, Brianna M; Urquhart, Siri A et al. (2015) Overexpression of mutant amyloid-? protein precursor and presenilin 1 modulates enteric nervous system. J Alzheimers Dis 44:1263-78
Rojanathammanee, Lalida; Floden, Angela M; Manocha, Gunjan D et al. (2015) Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. J Neuroinflammation 12:42

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