Abstract

A.
Specific Aims /Hypotheses: 1. The Wnt signaling components are expressed and functional in developing murine embryonic palatal tissue. 2. The molecular interaction between Smads and dishevelled is mediated through specific domains and post-translational modifications. 3. Multiple levels of cross-talk exist between the TGFbeta and Wnt signaling pathways. 4. The Smad-dishevelled interaction influences the progression and outcome of signaling from each pathway.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR017702-01
Application #
6688000
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2002-09-30
Project End
2007-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Louisville
Department
Type
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Jin, Jiu-Zhen; Lei, Zhenmin; Lan, Zi-Jian et al. (2018) Inactivation of Fgfr2 gene in mouse secondary palate mesenchymal cells leads to cleft palate. Reprod Toxicol 77:137-142
Liu, Lingyun; He, Yan; Guo, Kaimin et al. (2017) Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage. Am J Pathol 187:2508-2519
Liu, Xiao; Tang, Luosheng; Liu, Yongqing (2017) Mouse Müller Cell Isolation and Culture. Bio Protoc 7:
Mukhopadhyay, Partha; Seelan, Ratnam S; Rezzoug, Francine et al. (2017) Determinants of orofacial clefting I: Effects of 5-Aza-2'-deoxycytidine on cellular processes and gene expression during development of the first branchial arch. Reprod Toxicol 67:85-99
Li, Shengqiang; Moore, Andrew K; Zhu, Jia et al. (2016) Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod 94:41
Lan, Zi-Jian; Hu, YunHui; Zhang, Sheng et al. (2016) GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor ? activity in breast cancer cells. Breast Cancer Res Treat 158:263-76
Neal, Rachel E; Chen, Jing; Webb, Cindy et al. (2016) Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring. Reprod Toxicol 65:414-424
Neal, Rachel E; Jagadapillai, Rekha; Chen, Jing et al. (2016) Developmental cigarette smoke exposure II: Kidney proteome profile alterations in 6 month old adult offspring. Reprod Toxicol 65:425-435
Warner, Dennis R; Smith, Scott C; Smolenkova, Irina A et al. (2016) Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression. Exp Cell Res 342:32-8
Neal, Rachel E; Jagadapillai, Rekha; Chen, Jing et al. (2016) Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring. Reprod Toxicol 65:436-447

Showing the most recent 10 out of 114 publications