This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this research is to identify and describe factors that may impactor demonstrate the preterm infant?s response to noxious stimuli via three pilot projects to be undertaken within the next year. The primary grant proposal will identify cerebral blood flow dynamics and vital signs associated withnoxious stimuli in the preterm infant population of less than and equal to 32 weeks gestational age as a first step in developing a predictive model for intraventricular hemorrhage. Three specific pilot projects are proposed. First, a study entitled ?Measurement Issues Related to Cerebral Blood Flow in the Neonatal Brain? will serve to provide the engineers on the major proposal with data on the use of Near Infrared Spectroscopy (NIRS) in the neonate. The second project, ?Peak and Sustained Noise Levels in the NICU? will document an environmental variable that may be a confounder in the NICU. The third project, to take place after the completion of projects one and two, will be ?Correlation of Maternal and Infant factors with Incidence of IVH in one NICU?. This project will be a retrospective chart review to provide demographic and care variables that may be of interest in the predictive model.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR017702-06A1
Application #
7720698
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-08-01
Project End
2009-05-31
Budget Start
2008-08-01
Budget End
2009-05-31
Support Year
6
Fiscal Year
2008
Total Cost
$64,376
Indirect Cost
Name
University of Louisville
Department
Dentistry
Type
Schools of Dentistry
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Jin, Jiu-Zhen; Lei, Zhenmin; Lan, Zi-Jian et al. (2018) Inactivation of Fgfr2 gene in mouse secondary palate mesenchymal cells leads to cleft palate. Reprod Toxicol 77:137-142
Liu, Lingyun; He, Yan; Guo, Kaimin et al. (2017) Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage. Am J Pathol 187:2508-2519
Liu, Xiao; Tang, Luosheng; Liu, Yongqing (2017) Mouse Müller Cell Isolation and Culture. Bio Protoc 7:
Mukhopadhyay, Partha; Seelan, Ratnam S; Rezzoug, Francine et al. (2017) Determinants of orofacial clefting I: Effects of 5-Aza-2'-deoxycytidine on cellular processes and gene expression during development of the first branchial arch. Reprod Toxicol 67:85-99
Li, Shengqiang; Moore, Andrew K; Zhu, Jia et al. (2016) Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod 94:41
Lan, Zi-Jian; Hu, YunHui; Zhang, Sheng et al. (2016) GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor ? activity in breast cancer cells. Breast Cancer Res Treat 158:263-76
Neal, Rachel E; Chen, Jing; Webb, Cindy et al. (2016) Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring. Reprod Toxicol 65:414-424
Neal, Rachel E; Jagadapillai, Rekha; Chen, Jing et al. (2016) Developmental cigarette smoke exposure II: Kidney proteome profile alterations in 6 month old adult offspring. Reprod Toxicol 65:425-435
Warner, Dennis R; Smith, Scott C; Smolenkova, Irina A et al. (2016) Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression. Exp Cell Res 342:32-8
Neal, Rachel E; Jagadapillai, Rekha; Chen, Jing et al. (2016) Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring. Reprod Toxicol 65:436-447

Showing the most recent 10 out of 114 publications