This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Module of the COBRE serves all vision researchers on the OUHSC campus with high-quality animal care and technical assistance with vision-related experiments. Housing for mice, rats, and rabbits includes conventional, microisolation, and biohazard environments. Equipment available in the Animal Module includes systems for electroretinography, microsurgery, microinjection, vitrectomy, dark adaptation, light exposure, and digital photography and videography. Transgenic breeding colonies have been developed and established, facilitating the analysis of specific genes and factors involved in retinal degeneration, glaucoma, insulin receptor, diabetes, cytokine synthesis, and innate immune recognition systems. This varied collection of transgenic strains is available to all vision and non-vision researchers at OUHSC and has facilitated fruitful collaborations among researchers in differing areas of expertise. The Animal Module is the most heavily used COBRE module and is absolutely essential to the research programs of the COBRE PJIs and ECIs. Growth of vision research at OUHSC and subsequent increases in animal needs necessitates expansion into additional animal space on the OUHSC campus. An estimated doubling of available animal space is projected at DMEI with the completion of facility expansion in the next 2 years. These major improvements will facilitate the development of the COBRE PJIs'and ECIs'research programs and the growth of vision research at OUHSC.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017703-08
Application #
7959975
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2009-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
8
Fiscal Year
2009
Total Cost
$96,177
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Bhatti, Faizah; Kung, Johannes W; Vieira, Frederico (2018) Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PLoS One 13:e0199824
Vieira, Frederico; Kung, Johannes W; Bhatti, Faizah (2017) Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins. Ann Anat 211:184-201
Simón, María Victoria; Agnolazza, Daniela L; German, Olga Lorena et al. (2016) Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress. J Neurochem 136:931-46
Stiles, Megan; Qi, Hui; Sun, Eleanor et al. (2016) Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration. J Lipid Res 57:818-31
Bennett, Lea D; Anderson, Robert E (2016) Current Progress in Deciphering Importance of VLC-PUFA in the Retina. Adv Exp Med Biol 854:145-51
Ding, Xi-Qin; Thapa, Arjun; Ma, Hongwei et al. (2016) The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem 291:8721-34
Ma, Hongwei; Ding, Xi-Qin (2016) Thyroid Hormone Signaling and Cone Photoreceptor Viability. Adv Exp Med Biol 854:613-8
Cai, Xue; Chen, Lijuan; McGinnis, James F (2015) Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res 140:130-138
Bhatti, Faizah; Ball, Genevieve; Hobbs, Ronald et al. (2015) Pulmonary surfactant protein a is expressed in mouse retina by Müller cells and impacts neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 56:232-42
Rajala, Raju V S; Rajala, Ammaji; Morris, Andrew J et al. (2014) Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Sci Rep 4:5463

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