The overall objectives for the second five years of our COBRE program are to continue to improve the quality and quantity of VISION RESEARCH at the University of Oklahoma Hearth Sciences Center (OUHSC), to increase the long-term acquisition of NIH competitive funding in Oklahoma through the mentoring of project investigators and early career investigators (ECls), to recruit senior investigators to the OUHSC, and to develop support for the infrastructure of our vision research programs. This program is strongly supported by the leadership of the OUHSC and the Dean A. McGee Eye Institute (DMEI).
The specific aims of this COBRE renewal application are: A. To strengthen and to augment institutional biomedical research capabilities in vision research through the mentoring of project investigators by experienced, dedicated senior investigators. B. To broaden the research and mentoring capabilities of early career investigators by providing support for a second research project. C. To increase the critical mass of vision researchers at the OUHSC by recruiting four vision investigators. D. To enhance the infrastructure critical for expanding vision research in Oklahoma. E. To continue to foster collegial and collaborative relationships between COBRE investigators and other scientists. F. To oversee outcome milestones and expectations that will ensure the success of the COBRE program. G. To develop and implement an """"""""exit strategy"""""""" that will ensure continuity of the COBRE initiatives after the second 5 years of COBRE support.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017703-10
Application #
8113166
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Program Officer
Caldwell, Sheila
Project Start
2002-09-16
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$2,112,550
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Bhatti, Faizah; Kung, Johannes W; Vieira, Frederico (2018) Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. PLoS One 13:e0199824
Vieira, Frederico; Kung, Johannes W; Bhatti, Faizah (2017) Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins. Ann Anat 211:184-201
Simón, María Victoria; Agnolazza, Daniela L; German, Olga Lorena et al. (2016) Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress. J Neurochem 136:931-46
Stiles, Megan; Qi, Hui; Sun, Eleanor et al. (2016) Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration. J Lipid Res 57:818-31
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Ding, Xi-Qin; Thapa, Arjun; Ma, Hongwei et al. (2016) The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem 291:8721-34
Ma, Hongwei; Ding, Xi-Qin (2016) Thyroid Hormone Signaling and Cone Photoreceptor Viability. Adv Exp Med Biol 854:613-8
Cai, Xue; Chen, Lijuan; McGinnis, James F (2015) Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res 140:130-138
Bhatti, Faizah; Ball, Genevieve; Hobbs, Ronald et al. (2015) Pulmonary surfactant protein a is expressed in mouse retina by Müller cells and impacts neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 56:232-42
Ding, Xi-Qin; Matveev, Alexander; Singh, Anil et al. (2014) Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry. Adv Exp Med Biol 801:57-65

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