Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aims of the Core D facility are to provide infrastructure and support for structural analysis and metabolomics of cancer cells and tissue, and for producing proteins in high yield suitable for NMR analysis. This includes stable isotope labeling strategies including 15N and 13C precursors. Our goals continue to be to streamline both data collection and analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018733-04
Application #
7382009
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
4
Fiscal Year
2006
Total Cost
$129,105
Indirect Cost

  Institution

Name
University of Louisville
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Neely, Aaron M; Zhao, Guoping; Schwarzer, Christian et al. (2018) N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts. Cell Microbiol 20:
Schmidt, M Lee; Hobbing, Katharine R; Donninger, Howard et al. (2018) RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis. Cancer Res 78:2614-2623
Garbett, Nichola C; Brock, Guy N; Chaires, Jonathan B et al. (2017) Characterization and classification of lupus patients based on plasma thermograms. PLoS One 12:e0186398
Kendrick, Sarah K; Zheng, Qi; Garbett, Nichola C et al. (2017) Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients. PLoS One 12:e0186232
Zhao, Guoping; Neely, Aaron M; Schwarzer, Christian et al. (2016) N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins. Oncotarget 7:5924-42
Garbett, Nichola C; Brock, Guy N (2016) Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples. Biochim Biophys Acta 1860:981-989
Donninger, Howard; Schmidt, M Lee; Mezzanotte, Jessica et al. (2016) Ras signaling through RASSF proteins. Semin Cell Dev Biol 58:86-95
Lanceta, Lilibeth; Mattingly, Jacob M; Li, Chi et al. (2015) How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. PLoS One 10:e0134144
Schwarzer, Christian; Fu, Zhu; Morita, Takeshi et al. (2015) Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone. J Biol Chem 290:7247-58
Donninger, Howard; Calvisi, Diego F; Barnoud, Thibaut et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208:777-89

Showing the most recent 10 out of 148 publications