This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Pseudomonas aeruginosa is the most common cause of morbidity and mortality in patients with cystic fibrosis (CF). Sputum from CF patients colonized with P. aeruginosa have detectable levels of 3OC12HSL and other secreted signaling molecules known to regulate virulence factors, and previous studies have found that at least one of these molecules, 3OC12HSL, causes damage to host cells. In P. aeruginosa biofilms on C. albicans, 3OC12HSL concentrations are 8-12 fold higher than in equivalent planktonic P. aeruginosa cultures, we hypothesize that the host environment may similarly regulate 3OC12HSL production. The goal of this project is to examine the production kinetics and host effects of P. aeruginosa quorum sensing molecules.
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