An understanding of unique properties of stem and progenitor cells is advancing rapidly. Initial successes in manipulating such cells for therapeutic advantages have intensified investigations (and enabled national centers that focus on embryonic stem cell plasticity, adult stem cell sources &potentials, and therapies for defined disorders). This revolution has opened new doors, but has also raised important new questions concerning key niche-specific regulators of progenitor cell growth, survival, and development. Our COBRE Program has been developed to address such questions. In Phase-l, we have: assembled a thematically focused team of talented investigators;engaged expert IAC, EAC and mentoring components;acquired several R01 and K01 awards;made major infrastructural advances (e.g., new cores in cell separation, histopathology, bioinformatics and a new research building addition);and have extended intra-inter Institute interactions. Impacting scientific discoveries also have been made. In Phase-ll, aims are to: #1 Support six exciting new research projects to advance mechanistic understanding of blood, vascular, neural, and skeletal muscle progenitor cell development in important disease and injury contexts;#2 Guide additional investigators to R01 funded status, recruit an additional senior scientist and at least two additional outstanding new junior investigators to bolster our Program;#3 Further develop key core facilities;#4 Continue to fortify infrastructure (new research wing, State biomedical bonds);and #5 Support new interactive seed projects towards synergistic co-investigator programs, and grant support. We will continue to investigate important niche-specific progenitor cell problems, and will focus on: BMP orthologue regulation of kidney response to injury and regeneration;R-spondin2 as a novel candidate regulator of skeletal muscle regeneration;Mechanisms of mural cell assisted de novo blood vessel formation from hES cells;DNA break repair in stem cells and affected microenvironments during lymphomagenesis;Slug as a key regulator of hematopoietic stem cell survival;and Jagged 1 maintenance of neural stem cell expansion and pluripotency. These projects share common scientific (and clinically relevant) themes;will foster state and national interactions;will advance the field (and funding) in significant ways;and will attract additional high caliber investigators to our Program. Overall efforts will forge a nationally competitive Center in this exciting discipline.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018789-09
Application #
8102872
Study Section
Special Emphasis Panel (ZRR1-RI-6 (01))
Program Officer
Douthard, Regine
Project Start
2003-09-30
Project End
2013-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
9
Fiscal Year
2011
Total Cost
$1,982,725
Indirect Cost
Name
Maine Medical Center
Department
Type
DUNS #
071732663
City
Portland
State
ME
Country
United States
Zip Code
04102
Duarte, Christine W; Black, Adam W; Lucas, F Lee et al. (2017) Cancer incidence in patients with hereditary hemorrhagic telangiectasia. J Cancer Res Clin Oncol 143:209-214
Caron, Jennifer M; Ames, Jacquelyn J; Contois, Liangru et al. (2016) Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope. Am J Pathol 186:1649-61
Stohn, J Patrizia; Wang, Qiaozeng; Siviski, Matthew E et al. (2015) Cthrc1 controls adipose tissue formation, body composition, and physical activity. Obesity (Silver Spring) 23:1633-42
Ufkin, Melanie L; Peterson, Sarah; Yang, Xuehui et al. (2014) miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. Leuk Res 38:402-10
He, Qing; Yang, Xuehui; Gong, Yan et al. (2014) Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. J Bone Miner Res 29:1217-31
Motyl, Katherine J; Bishop, Kathleen A; DeMambro, Victoria E et al. (2013) Altered thermogenesis and impaired bone remodeling in Misty mice. J Bone Miner Res 28:1885-97
Hasham, Muneer G; Snow, Kathy J; Donghia, Nina M et al. (2012) Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. J Immunol 189:2374-82
Singh, Seema; Dev, Arvind; Verma, Rakesh et al. (2012) Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. PLoS One 7:e38530
Apra, Caroline; Richard, Laurence; Coulpier, Fanny et al. (2012) Cthrc1 is a negative regulator of myelination in Schwann cells. Glia 60:393-403
Krebs, Luke T; Bradley, Cara K; Norton, Christine R et al. (2012) The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis 50:366-74

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