Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The objective of this study is to explore the mechanisms of virus control and immune protection in SIVmac-infected long term nonprogressors (LTNP) rhesus macaques of Chinese-origin (Ch Rh). This will be done by a combination of retrospective analysis of archived samples as well as prospective study on 7 SIVmac239-infected Ch Rh. We hypothesize that the breadth, magnitude and specificity of the immune responses will distinguish progressors and LTNP. The knowledge obtained from Ch Rh LTNP may provide implications to design more efficacious vaccines or novel therapeutic approaches to combat HIV-1 infection.
The specific aims are:SA 1): To compare functional virus-specific and innate immune responses in both mucosal and systemic lymphoid tissues of SIV-infected progressing, and LTNP Ch Rh macaques. SA 2): To examine and compare gene regulation in mucosal and systemic lymphoid tissues of progressing and LTNP Ch Rh macaques infected with SIV. SA 3): To examine virologic factors in LTNP and progressors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR020159-05
Application #
7720434
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2008-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
5
Fiscal Year
2008
Total Cost
$98,484
Indirect Cost

  Institution

Name
Louisiana State University A&M Col Baton Rouge
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803

  Publications

Crossland, Nicholas A; Alvarez, Xavier; Embers, Monica E (2018) Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques. Am J Pathol 188:672-682
Cheemarla, Nagarjuna R; Baños-Lara, Ma Del Rocío; Naidu, Shan et al. (2017) Neutrophils regulate the lung inflammatory response via ?? T cell infiltration in an experimental mouse model of human metapneumovirus infection. J Leukoc Biol 101:1383-1392
Cai, S; Batra, S; Del Piero, F et al. (2016) NLRP12 modulates host defense through IL-17A-CXCL1 axis. Mucosal Immunol 9:503-14
Cai, S; Batra, S; Langohr, I et al. (2016) IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol 9:718-29
Gautam, Uma Shankar; Mehra, Smriti; Kaushal, Deepak (2015) In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice. PLoS One 10:e0135208
Mehra, Smriti; Foreman, Taylor W; Didier, Peter J et al. (2015) The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence. Am J Respir Crit Care Med 191:1185-96
Baños-Lara, Ma Del Rocío; Harvey, Lindsey; Mendoza, Alexander et al. (2015) Impact and regulation of lambda interferon response in human metapneumovirus infection. J Virol 89:730-42
Caskey, John R; Embers, Monica E (2015) Persister Development by Borrelia burgdorferi Populations In Vitro. Antimicrob Agents Chemother 59:6288-95
Pornwiroon, Walairat; Bourchookarn, Apichai; Paddock, Christopher D et al. (2015) Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii. Ticks Tick Borne Dis 6:829-35
Baños-Lara, Ma Del Rocío; Piao, Boyang; Guerrero-Plata, Antonieta (2015) Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells. Mediators Inflamm 2015:347292

Showing the most recent 10 out of 101 publications