The Center for Pediatric Research (CPR) was organized by networking a motivated group of scientists and physicians dedicated to the development and expansion of translational pediatric research. Common barriers that impede translational research were eliminated by integrating researchers from a number major disciplines in pediatric research, enabling a focus on mentored research training for physician and scientists to be maintained. This team approach to solving clinical research questions has transformed the research and clinical programs at Nemours. Our goal over the next five years is to establish the CPR as a sustainable center that drives translational research at Nemours. Building upon our existing strengths in genetics and neuroscience, we have selected four new investigators for support whose research programs fit within the expertise of our faculty mentors. This narrower focus will enable the CPR to establish a critical mass of investigators with overlapping research interests to attract funding and recruit new investigators needed to create a sustainable research center. A priority goal in the next cycle will be attracting additional senior faculty to the CPR to strengthen and expand our the core intellectual infrastructure. The center will be established further by integration into a state-wide network of research centers with a focus on translational research.
The aims of this proposal are: 1) To provide the infrastructure to train basic and physician scientists in their quest to become investigators who can procure independent funding for their respective programs;2) To facilitate the development of a multidisciplinary network of physicians and scientists to collaborate on basic and applied research on pediatric disorders;3) To develop translational research programs within the NCRR network in the Delaware Valley to enrich the interface between clinical and basic research. The uniqueness of the CPR is that it has been developed specifically to provide a multidisciplinary training program for pediatric research. The long-term goal is to establish the CPR as the key infrastructural center that acts as a catalyst to develop all research programs at Nemours that are dedicated to translating research discoveries into new therapies for the benefit of children in Delaware.

Public Health Relevance

(provided by applicant): The CPR is uniquely poised to drive the growth of translational research programs focused on pediatric diseases. The CPR's goals over the next five years are to expand faculty development programs and the reaches of the CPR within the institution and the state. These activities will increase the number of NIH funded research programs and significantly impact translational research activities in Delaware.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR020173-06A1
Application #
7938367
Study Section
Special Emphasis Panel (ZRR1-CR-B (01))
Program Officer
Gorospe, Rafael
Project Start
2004-09-07
Project End
2015-06-30
Budget Start
2010-09-17
Budget End
2011-06-30
Support Year
6
Fiscal Year
2010
Total Cost
$1,887,088
Indirect Cost
Name
Alfred I. Du Pont Hosp for Children
Department
Type
DUNS #
038004941
City
Wilmington
State
DE
Country
United States
Zip Code
19803
Nagao, Kyoko; Morlet, Thierry; Haley, Elizabeth et al. (2018) Neurophysiology of hearing in patients with mucopolysaccharidosis type IV. Mol Genet Metab 123:472-478
Brescia, AnneMarie C; Simonds, Megan M; McCahan, Suzanne M et al. (2018) Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable. Pediatr Rheumatol Online J 16:3
Brescia, AnneMarie C; Simonds, Megan M; Sullivan, Kathleen E et al. (2017) Secretion of pro-inflammatory cytokines and chemokines and loss of regulatory signals by fibroblast-like synoviocytes in juvenile idiopathic arthritis. Proteomics Clin Appl 11:
Kubaski, Francyne; Brusius-Facchin, Ana Carolina; Mason, Robert W et al. (2017) Elevation of glycosaminoglycans in the amniotic fluid of a fetus with mucopolysaccharidosis VII. Prenat Diagn 37:435-439
Khan, Shaukat; Alméciga-Díaz, Carlos J; Sawamoto, Kazuki et al. (2017) Mucopolysaccharidosis IVA and glycosaminoglycans. Mol Genet Metab 120:78-95
Kubaski, Francyne; Suzuki, Yasuyuki; Orii, Kenji et al. (2017) Glycosaminoglycan levels in dried blood spots of patients with mucopolysaccharidoses and mucolipidoses. Mol Genet Metab 120:247-254
Tomatsu, Shunji; Azario, Isabella; Sawamoto, Kazuki et al. (2016) Neonatal cellular and gene therapies for mucopolysaccharidoses: the earlier the better? J Inherit Metab Dis 39:189-202
Khan, Shaukat A; Dong, Hailong; Joyce, Jennifer et al. (2016) Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-?. Lab Invest 96:773-83
Yabe, Hiromasa; Tanaka, Akemi; Chinen, Yasutsugu et al. (2016) Hematopoietic stem cell transplantation for Morquio A syndrome. Mol Genet Metab 117:84-94
Robbins, Alan K; Mateson, Abigail B; Khandha, Ashutosh et al. (2016) Fetal Rat Gubernaculum Mesenchymal Cells Adopt Myogenic and Myofibroblast-Like Phenotypes. J Urol 196:270-8

Showing the most recent 10 out of 161 publications