This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The imaging core will provide the following services for COBRE investigators: LaserScanning Confocal Microscopy, with capability for microinjection and micromanipulation,sophisticated image analysis programs with a dedicated computerworkstation; transmission electron microscopy to be used for confirming cellularapoptosis; laser capture microdissection for isolating normal and cancer cells fromhistological specimens. This core will provide investigator/technician training if desiredfor individual laboratory use of the instruments. Alternatively, the core will providecomplete specimen analysis using its own personnel. COBRE members will havepriority in use of these imaging services when demand is high from other members of theUniversity community. Also, COBRE members will receive a 50% offset fromcustomary charges. The core Director and appropriate technical personnel will work withCOBRE investigators in experimental design and specimen preparation so that highquality data will be obtained.iCOB rno=p
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