This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ADMINISTRATIVE / INTELLECTUAL CORE The clear purpose of the COBRE program in general, and this core in particular, is Career Development of the junior faculty. This will be provided in the form of: Mentors: two per junior faculty plus the expertise of the Internal and External Advisors and speakers Courses: grant writing, survival skills, ethics, and on the techniques of the other cores in Microarray and Proteomics Assistant with grant preparations through presentations of Specific Aims at laboratory meetings and retreats Seminar Series of outstanding outside speakers relevant to the theme of the COBRE program Assisting with recruitment of graduate students and postdoctoral fellows through COBRE fellowships Developing new P01 Program Project Grants and T32 Training Grants This proposal describes an administrative structure designed to provide mentoring of an initial five junior faculty and three new faculty recruits to facilitate development of their research competitiveness and to increase the overall research and intellectual infrastructure in Immunobiology/Infectious Diseases at UVM through the development of the Vermont Immunobiology/Infectious Diseases Center (VIC). Program and core administration will be provided by the COBRE Director, Dr. Ralph Budd, with the assistance of a Co-Director, Dr. Gary Ward. A total of seven senior scientists within the institution will also serve as mentors for five junior faculty. Each junior scientist is assigned two senior scientist mentors. Interactions will occur at several levels: between primary mentors and junior faculty, between Director/Co-Director and junior faculty, among the entire COBRE group, and between the COBRE group and the External Advisory Committee. Advancing the intellectual infrastructure in Immunobiology/Infectious Diseases at UVM will be accomplished by developing a VIC Seminar Series comprising outstanding external investigators and an annual VIC retreat. In addition, either Dr. Budd or Dr. Ward will travel to Bethesda, MD once per year to meet with NCRR staff to discuss the direction of the COBRE and to benefit from the ideas of other COBRE Directors. The major outcomes of establishing a successful COBRE are expected to be submission of competitive R01 s by each of the junior faculty, submission of a second P01 Program Project Grant on Innate Immune Responses to Pathogens (the Immunobiology faculty already share one on Molecular Mechanisms of Thl/Th2 Cytokine Development) by the COBRE faculty, and successful competition for a T32 Training Grant for graduate education at UVM in Immunobiology/Infectious Diseases (one has just been submitted).
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