Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Infrastructure: Alterations and RenovationsUsing the Year 1 one-time renovation funds we have begun construction of a BSL2+ animal facility, that is needed immediately for work by one of us (Dr. Bonney for LCMV work in vivo), and is anticipated to be required for new faculty recruits. This is a jointly funded operation by the Deans office in the College of Medicine and the COBRE funds. It will supply space with state-of-the-art equipment for the handling of mice infected with various pathogens that require special precautions. This includes a barrier facility with air-lock entrance, pass-through autoclave, microtomes, tissue culture hoods, incubators, and microscopes that are dedicated to the facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021905-02
Application #
7610755
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2007-07-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$199,833
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

King, Benjamin R; Samacoits, Aubin; Eisenhauer, Philip L et al. (2018) Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence. J Virol 92:
Ziegler, Christopher M; Bruce, Emily A; Kelly, Jamie A et al. (2018) The use of novel epitope-tagged arenaviruses reveals that Rab5c-positive endosomal membranes are targeted by the LCMV matrix protein. J Gen Virol 99:187-193
Hasan, Muhammad M; Teixeira, Jose E; Huston, Christopher D (2018) Invadosome-Mediated Human Extracellular Matrix Degradation by Entamoeba histolytica. Infect Immun 86:
King, Benjamin R; Hershkowitz, Dylan; Eisenhauer, Philip L et al. (2017) A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol 91:
Bonney, Elizabeth A; Howard, Ann; Krebs, Kendall et al. (2017) Impact of Immune Deficiency on Remodeling of Maternal Resistance Vasculature 4 Weeks Postpartum in Mice. Reprod Sci 24:514-525
King, Benjamin R; Kellner, Samuel; Eisenhauer, Philip L et al. (2017) Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. J Gen Virol :
Bonney, Elizabeth A (2017) Alternative theories: Pregnancy and immune tolerance. J Reprod Immunol 123:65-71
Ziegler, Christopher M; Eisenhauer, Philip; Kelly, Jamie A et al. (2017) A proteomic survey of Junín virus interactions with human proteins reveals host factors required for arenavirus replication. J Virol :
Bonney, Elizabeth A; Krebs, Kendall; Saade, George et al. (2016) Differential senescence in feto-maternal tissues during mouse pregnancy. Placenta 43:26-34
Sateriale, Adam; Miller, Peter; Huston, Christopher D (2016) Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells. Infect Immun 84:1045-1053

Showing the most recent 10 out of 143 publications