This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The Sourcing and Acquisition core is designed to interface natural products and related compounds with CORE-NPN investigators. The National Center for Natural Products Research (NCNPR) was created to bring together an alliance of academia (The University of Mississippi), government, and the pharmaceutical and agrochemical industries to integrate research, development, and commercialization of potentially useful natural products. The NCNPR is the nation's only university-affiliated research center devoted to discovering, developing and commercializing new Pharmaceuticals and agrochemicals derived from natural products. This complements the chemistry core (Core B) which interfaces between the medicinal chemistry and pharmacognosy investigators associated with CORE-NPN and other researchers in the college of pharmacy and NCNPR. In comparison to the plant extracts held in the biomas:; collections and prepared extracts, i.e. the NCNPR Repositories, pharmacognosy investigators have numerous compounds from aquatic species while medicinal chemists have numerous compounds built around natural product (or synthetic) templates. Together there are over 10,000 extracts or pure compounds in-hous& Objectives: The Sourcing and Acquisition Core will provide two services to CORE-NPN investigators. The primary function of the core will be to provide a gateway resource to the extensive repositories that already reside in-house. Specifically, the core will update the existing stand-alone relational management database for the NCNPR to one that allows for network access and is capable of handling chemical structures. Core A will also provide the technical staff and expertise to train investigators on its use and maintain its function. The Sourcing and Acquisition Core's staff will also provide CORE-NPN investigators rapid access to the material extracts that reside in the NCNPR and Core B repositories as well as access to collections that reside with collaborators. The second mission of the Sourcing and Acquisition Core is to provide for the re-acquisition of compounds that investigators have exhausted from the repository. The following diagram displays the current methodology used by both the NCNPR and the department of Pharmacognosy.
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