Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project 4 proposes to use multimodal imaging to investigate whether general cognitive functioning in schizophrenia is related to circuit level white matter, metabolic, and volumetric changes in subcortical grayand white-matter regions suggestive of fronto-subcortical disconnection (Jung &Haier, 2007;Cummings 1993). Simultaneous utilization of Diffusion Tensor Imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS), and structural Magnetic Resonance Imaging (sMRI) will allow us to relate white matter abnormalities to both cortical and subcortical metabolic and morphological changes that, in turn, may underlie ongoing neurocognitive decline in schizophrenia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR021938-02
Application #
7960407
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2009-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
2
Fiscal Year
2009
Total Cost
$259,614
Indirect Cost

  Institution

Name
The Mind Research Network
Department
Type
DUNS #
098640696
City
Albuquerque
State
NM
Country
United States
Zip Code
87106

  Publications

Trapp, Cameron; Vakamudi, Kishore; Posse, Stefan (2018) On the detection of high frequency correlations in resting state fMRI. Neuroimage 164:202-213
Yu, Qingbao; Du, Yuhui; Chen, Jiayu et al. (2018) Application of Graph Theory to Assess Static and Dynamic Brain Connectivity: Approaches for Building Brain Graphs. Proc IEEE Inst Electr Electron Eng 106:886-906
Du, Yuhui; Fryer, Susanna L; Lin, Dongdong et al. (2018) Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study. Neuroimage Clin 17:335-346
Du, Yuhui; Fryer, Susanna L; Fu, Zening et al. (2018) Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis. Neuroimage 180:632-645
Edgar, J C; Fisk 4th, Charles L; Chen, Yu-Han et al. (2018) Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures. Psychophysiology 55:e13074
Thoma, Robert J; Haghani Tehrani, Poone; Turner, Jessica A et al. (2018) Neuropsychological analysis of auditory verbal hallucinations. Schizophr Res 192:459-460
Sanfratello, Lori; Aine, Cheryl; Stephen, Julia (2018) Neuroimaging investigations of dorsal stream processing and effects of stimulus synchrony in schizophrenia. Psychiatry Res Neuroimaging :
Wu, Lei; Caprihan, Arvind; Bustillo, Juan et al. (2018) An approach to directly link ICA and seed-based functional connectivity: Application to schizophrenia. Neuroimage 179:448-470
Mennigen, Eva; Miller, Robyn L; Rashid, Barnaly et al. (2018) Reduced higher-dimensional resting state fMRI dynamism in clinical high-risk individuals for schizophrenia identified by meta-state analysis. Schizophr Res 201:217-223
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163

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